ArticleJournal of nephrology2014
Proton-pump inhibitors do not influence serum magnesium levels in renal transplant recipients.
Article in Journal of nephrology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Pooled it
- Does the use of proton pump inhibitors increase the risk of hypomagnesemia: An updated systematic review and meta-analysis.Medicine · 2019Pooled it
- The association between the use of proton pump inhibitors and the risk of hypomagnesemia: a systematic review and meta-analysis.PloS one · 2014Pooled it
- Article
- Proton-pump inhibitor use amongst patients with severe hypomagnesemia.Frontiers in pharmacology · 2023Article
- Proton-Pump Inhibitors and Hypomagnesaemia in Kidney Transplant Recipients.Journal of clinical medicine · 2019Article
- Proton pump inhibitors and adverse effects in kidney transplant recipients: A meta-analysis.World journal of transplantation · 2019Article
- Extreme hypomagnesemia: characteristics of 119 consecutive inpatients.Internal and emergency medicine · 2018Observational
- The relationship between proton pump inhibitor use and serum magnesium concentration among hemodialysis patients: a cross-sectional study.BMC nephrology · 2015Article
- Proton pump inhibitor use is not associated with cardiac arrhythmia in critically ill patients.Journal of clinical pharmacology · 2015Article
- Hypomagnesemia Induced by Long-Term Treatment with Proton-Pump Inhibitors.Gastroenterology research and practice · 2015Review
- Long-term Effects of Gastric Acid Prophylaxis in Kidney Transplant Recipients.Revista de nefrologia, dialisis y transplante : publicacion conjunta de la Asociacion Regional de Dialisis y Trasplantes Renales de Capital Federal y Provincia de Buenos Aires y la Sociedad Argentina de NefrologiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe hypomagnesemia has been reported with use of proton-pump inhibitors (PPIs). We assessed the effect, if any, of PPI use on serum magnesium level in a cross-sectional analysis of a large published cohort of renal transplant recipients (RTRs). Between February 2004 and February 2006, 512 consecutive prevalent RTRs were enrolled at two university hospitals in Belgium (Brussels and Ghent). Serum creatinine was 1.5 ± 0.7 mg/dl, and estimated glomerular filtration rate (eGFR) 53 ± 19 ml/min/1.73 m(2). Mean (and median) magnesium level was 1.91 ± 0.23 mg/dl. PPIs were prescribed in 20 % (n = 101) of cases. At multivariable analysis, PPI use was not an independent predictor of serum magnesium level or hypomagnesemia. The independent predictors of a lower serum magnesium level were the use of tacrolimus, cyclosporin and sirolimus, the absence of use of mycophenolate mofetil, lower levels of parathyroid hormone and higher eGFR. This study is the first to analyze the potential impact of PPIs on magnesium level in a large, representative cohort of RTR patients. Our results suggest that PPIs may be used without particular fear of favoring hypomagnesemia-related side effects in RTRs, an important finding in a population at high risk of hypomagnesemia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.