ArticlePlacenta2014
The effect of maternal prenatal smoking and alcohol consumption on the placenta-to-birth weight ratio.
Article in Placenta, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The maternal factors associated with infant low birth weight: an umbrella review.BMC pregnancy and childbirth · 2024Pooled it
- Smoking during pregnancy and its effect on placental weight: a Mendelian randomization study.BMC pregnancy and childbirth · 2024Pooled it
- Prevalence and Patterns of Prenatal Alcohol Exposure in Australian Cohort and Cross-Sectional Studies: A Systematic Review of Data Collection Approaches.International journal of environmental research and public health · 2022Pooled it
- Prevalence of prenatal alcohol use among Aboriginal and non-Aboriginal women in the Northern Territory, Australia: estimate from perinatal, emergency, and admission datasets.BMC pregnancy and childbirth · 2025Article
- The influence of perinatal high-risk behavior on maternal and neonatal health.Journal of education and health promotion · 2025Article
- Article
- Sex-specific alterations in cognitive control following moderate prenatal alcohol exposure and transient systemic hypoxia ischemia in the rat.Alcohol, clinical & experimental research · 2024Article
- On the Use of Minimum Penalties in Statistical Learning.Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America · 2024Article
- Placental volume in pregnant women with opioid use: prenatal MRI assessment.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2023Article
- Article
- A multi-organ analysis of the role of mTOR in fetal alcohol spectrum disorders.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Review
- Mortality of central nervous system tumors in pediatric patients of Brazil from 1979 to 2019.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- The impact of exposure to tobacco smoking and maternal trauma in fetal life on risk of migraine.Frontiers in neuroscience · 2023Article
- Binge alcohol drinking before pregnancy is closely associated with the development of macrosomia: Korean pregnancy registry cohort.PloS one · 2022Article
- Placental mTOR Signaling and Sexual Dimorphism in Metabolic Health across the Lifespan of Offspring.Children (Basel, Switzerland) · 2021Review
- Decreased head circumference at birth associated with maternal tobacco smoke exposure during pregnancy on the Japanese prospective birth cohort study.Scientific reports · 2021Article
- Nutrient transporter expression in both the placenta and fetal liver are affected by maternal smoking.Placenta · 2019Article
- Unequal Cumulative Incidence and Mortality Outcome in Childhood Brain and Central Nervous System Malignancy in the USA.Journal of racial and ethnic health disparities · 2018Article
- Placental weight and birthweight: the relations with number of daily cigarettes and smoking cessation in pregnancy. A population study.International journal of epidemiology · 2018Article
- Effect of Smoking Behavior before and during Pregnancy on Selected Birth Outcomes among Singleton Full-Term Pregnancy: A Murmansk County Birth Registry Study.International journal of environmental research and public health · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundMaternal influence on fetal growth is mediated through the placenta and this influence may have an implication for the offspring's long-term health. The placenta-to-birth weight ratio has been regarded as an indicator of placental function. However, few studies have examined the effect of maternal lifestyle exposures on the placenta-to-birth weight ratio. This study aims to examine the associations of maternal prenatal smoking and alcohol consumption with the placenta-to-birth weight ratio.
methodsData for 7945 term singletons, gestation≥37 weeks, were selected from the Tasmanian Infant Health Survey; a 1988-1995 Australian cohort study. Placenta and birth weight were extracted from birth notification records.
resultsMaternal smoking during pregnancy was strongly associated with a 6.77 g/kg higher (95% CI 4.83-8.71) placenta-to-birth weight ratio when compared to non-smoking mothers. Maternal prenatal smoking was associated with lower placental (β = -15.37 g; 95% CI -23.43 to -7.31) and birth weights (β = -205.49 g; 95% CI -232.91 to -178.08). Mothers who consumed alcohol during pregnancy had a lower placenta-to-birth weight ratio (β = -2.07 g/kg; 95% CI -4.01 to -0.12) than mothers who did not consume alcohol. The associations of maternal alcohol consumption during pregnancy with placental and birth weight did not reach statistical significance. DISCUSSION: Maternal prenatal smoking and alcohol consumption may influence fetal growth by either directly or indirectly altering the function of the placenta.
conclusionsThe alteration of the in utero environment induced by smoking and alcohol consumption appears to affect placental and fetal growth in differing ways. Further studies are needed to elucidate the mechanism.
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