SynthesisJournal of the National Cancer Institute2014
Mammographic density phenotypes and risk of breast cancer: a meta-analysis.
Registry-linked trialAbstract readMeta-AnalysisReview
In one paragraph
Synthesis in Journal of the National Cancer Institute, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05787249 (Improving Utilization of Supplemental Breast MRI Screening for Women With Extremely Dense Breasts), which is not on this map. Cited by 201 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
201citing papers in PubMed, 6 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Improving Utilization of Supplemental Breast MRI Screening for Women With Extremely Dense Breasts
Who cites it
201 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- The impact of mammographic breast density on locoregional recurrence in breast cancer: a systematic review and meta-analysis.Breast cancer research and treatment · 2025Pooled it
- The unique risk factor profile of triple-negative breast cancer: a comprehensive meta-analysis.Journal of the National Cancer Institute · 2024Pooled it
- Repeated measures of mammographic density and texture to evaluate prediction and risk of breast cancer: a systematic review of the methods used in the literature.Cancer causes & control : CCC · 2023Pooled it
- Effects of bariatric surgery on breast density in adult obese women: systematic review and meta-analysis.Frontiers in immunology · 2023Pooled it
- Studies of parenchymal texture added to mammographic breast density and risk of breast cancer: a systematic review of the methods used in the literature.Breast cancer research : BCR · 2022Pooled it
- Mammographic breast density and the risk of breast cancer: A systematic review and meta-analysis.Breast (Edinburgh, Scotland) · 2022Pooled it
- A randomized controlled trial of metformin in women with components of metabolic syndrome: intervention feasibility and effects on adiposity and breast density.Breast cancer research and treatment · 2021Trial
- The Influence of Vitamin D on Mammographic Density: Results from CALGB 70806 (Alliance) a Randomized Clinical Trial.Cancer prevention research (Philadelphia, Pa.) · 2021Trial
- Effect of Metformin on Breast Density in Overweight/Obese Premenopausal Women.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Trial
- Intake of dietary carbohydrates in early adulthood and adolescence and breast density among young women.Cancer causes & control : CCC · 2018Trial
- Early Life Body Fatness, Serum Anti-Müllerian Hormone, and Breast Density in Young Adult Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016Trial
- Geographic variation in volumetric breast density between screening regions in the Netherlands.European radiology · 2015Trial
- Adolescent endogenous sex hormones and breast density in early adulthood.Breast cancer research : BCR · 2015Trial
- Comparison of three algorithms to measure breast density on mammograms in a population-based screening cohort.European radiology · 2026Article
- Early-adulthood body mass index, mammographic density and post-menopausal breast cancer risk: a mediation analysis.British journal of cancer · 2026Article
- Serum perfluoroalkyl substances (PFASs) concentrations and associations with mammographic density in postmenopausal women.Breast cancer research : BCR · 2026Article
- Longitudinal Mammographic Breast Density Changes and Associated Factors in Older Korean Women.Radiology. Imaging cancer · 2026Article
- Interactions between genetic and epidemiological factors influencing mammographic density.American journal of epidemiology · 2026Article
- Advancements in Developing an Automated Breast Density Detection Technique for Breast Cancer Risk Prediction: Synthesizing a Signal-dependent Noise Stochastic Process.bioRxiv : the preprint server for biology · 2026Article
- Obesity and breast density enhance immune exclusion in the primary tumor microenvironment and promote breast cancer metastasis.Oncogene · 2026Article
141 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
30 authors.
Andreas PetterssonAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
Rebecca E GraffAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
Giske UrsinAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
Isabel Dos Santos SilvaAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
Valerie McCormackAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
Laura BagliettoAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
Celine VachonAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
Marije F BakkerAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
Graham G GilesAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
Kee Seng ChiaAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
Kamila CzeneAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
Louise ErikssonAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
Per HallAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
Mikael HartmanAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
Ruth M L WarrenAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
Greg HislopAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
Anna M ChiarelliAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
John L HopperAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
Kavitha KrishnanAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
Jingmei LiAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
Qing LiAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
Ian PaganoAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
Bernard A RosnerAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
Chia Siong WongAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
Christopher ScottAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
Jennifer StoneAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
Gertraud MaskarinecAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
Norman F BoydAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
Carla H van GilsAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
Rulla M TamimiAffiliations of authors: Department of Epidemiology (AP, REG, RMT), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (GU); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (GU); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (IdSS); Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France (VM); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, GGG, KK); Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Melbourne, Australia (LB, GGG, JLH, KK, JS); Division of Epidemiology (CV) and Division of Biomedical Statistics and Informatics (CS), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (MFB, CHvG); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (GGG); Saw Swee Hock School of Public Health (KSC, MH, CSW), and Department of Surgery, Yong Loo Lin School of Medicine (MH), National University of Singapore, National University Health System, Singapore, Singapore; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, LE, PH, MH); Department of Radiology, Addenbrooke's Hospital, Cambridge, UK (RMLW); School of Population and Public Health, University of British Columbia, Vancouver, BC , Canada (GH); Prevention and Cancer Control, Cancer Care, Toronto, ON, Canada (AMC); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JL); Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada (QL, NFB); University of Hawaii Cancer Center, Honolu
Funding
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Felicity Enders · 1985 to 2026
$151.3MStatistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8MUniversity of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Xin Chen · 1996 to 2026
$56.2MThe Role of CHFR in Tumorigenesis and Paclitaxel-Sensitivity in Breast CancerP50CA116201 · NCI · MAYO CLINIC ROCHESTER · PI PETER C LUCAS · 2005 to 2026
$49.9MRisk Factors for Breast Cancer in Younger NursesR01CA050385 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 1989 to 2019
$32.3MMultiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2MNutritional Epidemiology of Cancer Education and Career Development ProgramR25CA098566 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI STAMPFER, MEIR · 2003 to 2013
$4.5MA Mayo Cohort Study of Mammographic Breast DensityR01CA097396 · NCI · MAYO CLINIC ROCHESTER · PI VACHON, CELINE M · 2003 to 2007
$3.1MIdentifying Genes for Mammographic Breast DensityR01CA128931 · NCI · MAYO CLINIC ROCHESTER · PI VACHON, CELINE M · 2008 to 2012
$2.7MRisk factors for breast cancer molecular subtypesR01CA140286 · NCI · MAYO CLINIC ROCHESTER · PI KERLIKOWSKE, KARLA M, VACHON, CELINE M · 2010 to 2014
$2.6MWhole Genome Association Study of Mammographic DensityR01CA131332 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TAMIMI, RULLA M · 2009 to 2012
$1.9MMolecular Predictors of Mammographic DensityR01CA124865 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TAMIMI, RULLA M · 2008 to 2011
$1.2MBreast Cancer Now 2007MAYPR23Cancer Research UK 14565NCI NIH HHS P01 CA87969NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA071789NCI NIH HHS P50 CA116201NCI NIH HHS R01 CA085265NCI NIH HHS R01 CA124865NCI NIH HHS R01 CA128931NCI NIH HHS R01 CA131332NCI NIH HHS R01 CA140286NCI NIH HHS R01 CA50385NCI NIH HHS R01 CA97396NCI NIH HHS R03 CA135699NCI NIH HHS R25 CA098566NCI NIH HHS R37 CA054281World Health Organization 001
Abstract
backgroundFibroglandular breast tissue appears dense on mammogram, whereas fat appears nondense. It is unclear whether absolute or percentage dense area more strongly predicts breast cancer risk and whether absolute nondense area is independently associated with risk.
methodsWe conducted a meta-analysis of 13 case-control studies providing results from logistic regressions for associations between one standard deviation (SD) increments in mammographic density phenotypes and breast cancer risk. We used random-effects models to calculate pooled odds ratios and 95% confidence intervals (CIs). All tests were two-sided with P less than .05 considered to be statistically significant.
resultsAmong premenopausal women (n = 1776 case patients; n = 2834 control subjects), summary odds ratios were 1.37 (95% CI = 1.29 to 1.47) for absolute dense area, 0.78 (95% CI = 0.71 to 0.86) for absolute nondense area, and 1.52 (95% CI = 1.39 to 1.66) for percentage dense area when pooling estimates adjusted for age, body mass index, and parity. Corresponding odds ratios among postmenopausal women (n = 6643 case patients; n = 11187 control subjects) were 1.38 (95% CI = 1.31 to 1.44), 0.79 (95% CI = 0.73 to 0.85), and 1.53 (95% CI = 1.44 to 1.64). After additional adjustment for absolute dense area, associations between absolute nondense area and breast cancer became attenuated or null in several studies and summary odds ratios became 0.82 (95% CI = 0.71 to 0.94; P heterogeneity = .02) for premenopausal and 0.85 (95% CI = 0.75 to 0.96; P heterogeneity < .01) for postmenopausal women.
conclusionsThe results suggest that percentage dense area is a stronger breast cancer risk factor than absolute dense area. Absolute nondense area was inversely associated with breast cancer risk, but it is unclear whether the association is independent of absolute dense area.
Indexed as
BreastBreast NeoplasmsCase-Control StudiesFemaleHumansMammographyMiddle AgedPhenotypePostmenopause
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT05787249ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.