Evidence map›Paper›PMID 24816094›Full record

ArticleActa crystallographica. Section D, Biological crystallography2014

Exploiting fast detectors to enter a new dimension in room-temperature crystallography.

Robin L Owen, Neil Paterson, Danny Axford, Jun Aishima, Clemens Schulze-Briese, Jingshan Ren, Elizabeth E Fry, David I Stuart, Gwyndaf Evans

Abstract read
In one paragraph

Article in Acta crystallographica. Section D, Biological crystallography, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Damage-limited resolution for X-ray and electron microscopy of organic specimens.Acta crystallographica. Section D, Structural biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. xia2.multiplex: a multi-crystal data-analysis pipeline.Acta crystallographica. Section D, Structural biology · 2022
    Article
  7. Article
  8. High-throughput in situ experimental phasing.Acta crystallographica. Section D, Structural biology · 2020
    Article
  9. Radiation damage and dose limits in serial synchrotron crystallography at cryo- and room temperatures.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. SLS-2 - the upgrade of the Swiss Light Source.Journal of synchrotron radiation · 2018
    Article
  15. Article
  16. Article
  17. Analysis of oscillatory rocking curve by dynamical diffraction in protein crystals.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  18. Article
  19. Where is crystallography going?Acta crystallographica. Section D, Structural biology · 2018
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Robin L OwenDiamond Light Source, Harwell Science and Innovation Campus, Didcot OX11 0DE, England.
Neil PatersonDiamond Light Source, Harwell Science and Innovation Campus, Didcot OX11 0DE, England.
Danny AxfordDiamond Light Source, Harwell Science and Innovation Campus, Didcot OX11 0DE, England.
Jun AishimaDiamond Light Source, Harwell Science and Innovation Campus, Didcot OX11 0DE, England.
Clemens Schulze-BrieseDectris Ltd, Neuenhofer Strasse 107, 5400 Baden, Switzerland.
Jingshan RenDivision of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, England.
Elizabeth E FryDivision of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, England.
David I StuartDiamond Light Source, Harwell Science and Innovation Campus, Didcot OX11 0DE, England.
Gwyndaf EvansDiamond Light Source, Harwell Science and Innovation Campus, Didcot OX11 0DE, England.

Funding

Medical Research Council G0701506Medical Research Council G1000099Medical Research Council G19/3Wellcome Trust 090532
6 · The paper itself

Abstract

A departure from a linear or an exponential intensity decay in the diffracting power of protein crystals as a function of absorbed dose is reported. The observation of a lag phase raises the possibility of collecting significantly more data from crystals held at room temperature before an intolerable intensity decay is reached. A simple model accounting for the form of the intensity decay is reintroduced and is applied for the first time to high frame-rate room-temperature data collection.

Indexed as

Crystallography, X-RayEnterovirus, BovineFoot-and-Mouth Disease VirusModels, TheoreticalProteinsTemperatureProteinsdose ratemacromolecular crystallographyradiation damageroom temperature

Identifiers

PMID24816094
PMCPMC4014120

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.