ArticleScientific reports2014
Polarization-sensitive hyperspectral imaging in vivo: a multimode dermoscope for skin analysis.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Medical hyperspectral imaging: an updated review of technology advancements and biomedical applications.Journal of biomedical optics · 2026Pooled it
- Hyperspectral and multispectral image processing for gross-level tumor detection in skin lesions: a systematic review.Journal of biomedical optics · 2022Pooled it
- A ComparativeBioMed research international · 2018Trial
- Differentiating solar lentigines from post-inflammatory hyperpigmentation with hyperspectral imaging: A pilot study.International journal of cosmetic science · 2026Article
- Validation of a handheld polarized hyperspectral imaging probe on intralipid phantom and mouse tissue.Proceedings of SPIE--the International Society for Optical Engineering · 2025Article
- Skin characterization of diabetes mellitus revealed by polarization-sensitive optical coherence tomography imaging.Journal of biomedical optics · 2024Article
- Polarized hyperspectral microscopic imaging system for enhancing the visualization of collagen fibers and head and neck squamous cell carcinoma.Journal of biomedical optics · 2024Article
- Measuring and imaging of transcutaneous bilirubin, hemoglobin, and melanin based on diffuse reflectance spectroscopy.Journal of biomedical optics · 2023Article
- Long-wave infrared photothermoelectric detectors with ultrahigh polarization sensitivity.Nature communications · 2023Article
- A birefringent spectral demultiplexer enables fast hyper-spectral imaging of protoporphyrin IX during neurosurgery.Communications biology · 2023Article
- Measuring changes in blood volume fraction during induced gingivitis of healthy and unhealthy populations using hyperspectral spatial frequency domain imaging: a clinical study.Scientific reports · 2022Article
- Advanced Wound Diagnostics: Toward Transforming Wound Care into Precision Medicine.Advances in wound care · 2022Review
- Biomedical Applications of Translational Optical Imaging: From Molecules to Humans.Molecules (Basel, Switzerland) · 2021Review
- Mantis shrimp-inspired organic photodetector for simultaneous hyperspectral and polarimetric imaging.Science advances · 2021Article
- Automatic detection of head and neck squamous cell carcinoma on pathologic slides using polarized hyperspectral imaging and machine learning.Proceedings of SPIE--the International Society for Optical Engineering · 2021Article
- Point-of-care, multispectral, smartphone-based dermascopes for dermal lesion screening and erythema monitoring.Journal of biomedical optics · 2020Article
- Role of scattering and birefringence in phase retardation revealed by locus of Stokes vector on Poincaré sphere.Journal of biomedical optics · 2020Article
- Simple and affordable imaging of multiple physiological parameters with RGB camera-based diffuse reflectance spectroscopy.Biomedical optics express · 2020Article
- Development of a new polarized hyperspectral imaging microscope.Proceedings of SPIE--the International Society for Optical Engineering · 2020Article
- Analysis of skin morphological features and real-time monitoring using snapshot hyperspectral imaging.Biomedical optics express · 2019Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Attempts to understand the changes in the structure and physiology of human skin abnormalities by non-invasive optical imaging are aided by spectroscopic methods that quantify, at the molecular level, variations in tissue oxygenation and melanin distribution. However, current commercial and research systems to map hemoglobin and melanin do not correlate well with pathology for pigmented lesions or darker skin. We developed a multimode dermoscope that combines polarization and hyperspectral imaging with an efficient analytical model to map the distribution of specific skin bio-molecules. This corrects for the melanin-hemoglobin misestimation common to other systems, without resorting to complex and computationally intensive tissue optical models. For this system's proof of concept, human skin measurements on melanocytic nevus, vitiligo, and venous occlusion conditions were performed in volunteers. The resulting molecular distribution maps matched physiological and anatomical expectations, confirming a technologic approach that can be applied to next generation dermoscopes and having biological plausibility that is likely to appeal to dermatologists.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.