Evidence map›Paper›PMID 24815335›Full record

ArticleEnvironmental research2014

Impact of urine concentration adjustment method on associations between urine metals and estimated glomerular filtration rates (eGFR) in adolescents.

Virginia M Weaver, Gonzalo García Vargas, Ellen K Silbergeld, Stephen J Rothenberg, Jeffrey J Fadrowski, Marisela Rubio-Andrade, Patrick J Parsons, Amy J Steuerwald, Ana Navas-Acien, Eliseo Guallar

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. A State-of-the-Science Review on Metal Biomarkers.Current environmental health reports · 2023
    Review
  9. Article
  10. Article
  11. Prenatal Metal Exposures and Infants' Developmental Outcomes in a Navajo Population.International journal of environmental research and public health · 2021
    Article
  12. Article
  13. Article
  14. Developmental toxicity of cadmium in infants and children: a review.Environmental analysis, health and toxicology · 2021
    Article
  15. Article
  16. Article
  17. Environmental Pollution and Chronic Kidney Disease.International journal of medical sciences · 2021
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Virginia M WeaverDepartment of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA; Johns Hopkins University School of Medicine, Baltimore, MD, USA; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. Electronic address: vweaver@jhsph.edu.
Gonzalo García VargasFaculty of Medicine, University of Juárez of Durango State, Durango, Mexico; Secretaría de Salud del Estado de Coahuila, Coahuila, México.
Ellen K SilbergeldDepartment of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Stephen J RothenbergInstituto Nacional de Salud Publica, Centro de Investigacion en Salud Poblacional, Cuernavaca, Morelos, Mexico.
Jeffrey J FadrowskiJohns Hopkins University School of Medicine, Baltimore, MD, USA; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Marisela Rubio-AndradeFaculty of Medicine, University of Juárez of Durango State, Durango, Mexico.
Patrick J ParsonsLaboratory of Inorganic and Nuclear Chemistry, Wadsworth Center, New York State Department of Health, Albany, NY, USA; Department of Environmental Health Sciences, School of Public Health, University at Albany, Albany, NY, USA.
Amy J SteuerwaldLaboratory of Inorganic and Nuclear Chemistry, Wadsworth Center, New York State Department of Health, Albany, NY, USA.
Ana Navas-AcienDepartment of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Eliseo GuallarJohns Hopkins University School of Medicine, Baltimore, MD, USA; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Johns Hopkins Medicine · USAutonomous University of Durango · MXJohns Hopkins University · USInstituto Nacional de Salud Pública · MXNew York State Department of Health · USWadsworth Center · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Lead, Cadmium,Arsenic, and cardiovascular risk in childrenR01ES015597 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI GUALLAR, ELISEO · 2009 to 2011
$1.5M
NCATS NIH HHS UL1 TR001079NIEHS NIH HHS R01 ES015597
6 · The paper itself

Abstract

Positive associations between urine toxicant levels and measures of glomerular filtration rate (GFR) have been reported recently in a range of populations. The explanation for these associations, in a direction opposite that of traditional nephrotoxicity, is uncertain. Variation in associations by urine concentration adjustment approach has also been observed. Associations of urine cadmium, thallium and uranium in models of serum creatinine- and cystatin-C-based estimated GFR (eGFR) were examined using multiple linear regression in a cross-sectional study of adolescents residing near a lead smelter complex. Urine concentration adjustment approaches compared included urine creatinine, urine osmolality and no adjustment. Median age, blood lead and urine cadmium, thallium and uranium were 13.9 years, 4.0 μg/dL, 0.22, 0.27 and 0.04 g/g creatinine, respectively, in 512 adolescents. Urine cadmium and thallium were positively associated with serum creatinine-based eGFR only when urine creatinine was used to adjust for urine concentration (β coefficient=3.1 mL/min/1.73 m(2); 95% confidence interval=1.4, 4.8 per each doubling of urine cadmium). Weaker positive associations, also only with urine creatinine adjustment, were observed between these metals and serum cystatin-C-based eGFR and between urine uranium and serum creatinine-based eGFR. Additional research using non-creatinine-based methods of adjustment for urine concentration is necessary.

Indexed as

Environmental MonitoringAdolescentChildCross-Sectional StudiesExtraction and Processing IndustryFemaleGlomerular Filtration RateHumansMaleMetals, HeavyMetals, HeavyCadmiumCreatinineOsmolalityUraniumUrine concentration

Identifiers

PMID24815335
PMCPMC4128831
OpenAlexW2060695589

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.