ArticleDevelopmental biology2014
Regulation of broad by the Notch pathway affects timing of follicle cell development.
Article in Developmental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- An exploratory analysis of the effects of human FYN and its Drosophila ortholog in Drosophila tissues.Scientific reports · 2026Article
- Germline protein, Cup, non-cell autonomously limits migratory cell fate in Drosophila oogenesis.PLoS genetics · 2023Article
- Standardization of Single-Cell RNA-Sequencing Analysis Workflow to Study Drosophila Ovary.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Developmental regulation of epithelial cell cuboidal-to-squamous transition in Drosophila follicle cells.Developmental biology · 2022Article
- An Automatic Stage Identification MATLAB Tool to Reveal Notch Expression Pattern in Drosophila Egg Chambers.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Analysis of the Temporal Patterning of Notch Downstream Targets during Drosophila melanogaster Egg Chamber Development.Scientific reports · 2020Article
- A single-cell atlas of adult Drosophila ovary identifies transcriptional programs and somatic cell lineage regulating oogenesis.PLoS biology · 2020Article
- NOTCH2/NOTCH3/DLL3/MAML1/ADAM17 signaling network is associated with ovarian cancer.Oncology letters · 2019Article
- Developmental regulation of regenerative potential in Drosophila by ecdysone through a bistable loop of ZBTB transcription factors.PLoS biology · 2019Article
- Article
- The Initial Stage of Tumorigenesis in Drosophila Epithelial Tissues.Advances in experimental medicine and biology · 2019Review
- Article
- A Genetic Mosaic Screen Reveals Ecdysone-Responsive Genes Regulating Drosophila Oogenesis.G3 (Bethesda, Md.) · 2016Article
- The Ecdysone and Notch Pathways Synergistically Regulate Cut at the Dorsal-Ventral Boundary in Drosophila Wing Discs.Journal of genetics and genomics = Yi chuan xue bao · 2016Article
- Automatic stage identification of Drosophila egg chamber based on DAPI images.Scientific reports · 2016Article
- Hindsight/RREB-1 functions in both the specification and differentiation of stem cells in the adult midgut of Drosophila.Biology open · 2015Article
- A large-scale in vivo RNAi screen to identify genes involved in Notch-mediated follicle cell differentiation and cell cycle switches.Scientific reports · 2015Article
- Analysis of Cell Cycle Switches in Drosophila Oogenesis.Methods in molecular biology (Clifton, N.J.) · 2015Article
- E(y)1/TAF9 mediates the transcriptional output of Notch signaling in Drosophila.Journal of cell science · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
During Drosophila oogenesis, activation of Notch signaling in the follicular epithelium (FE) around stage 6 of oogenesis is essential for entry into the endocycle and a series of other changes such as cell differentiation and migration of subsets of the follicle cells. Notch induces the expression of zinc finger protein Hindsight and suppresses homeodomain protein Cut to regulate the mitotic/endocycle (ME) switch. Here we report that broad (br), encoding a small group of zinc-finger transcription factors resulting from alternative splicing, is a transcriptional target of Notch nuclear effector Suppressor of Hairless (Su(H)). The early pattern of Br in the FE, uniformly expressed except in the polar cells, is established by Notch signaling around stage 6, through the binding of Su(H) to the br early enhancer (brE) region. Mutation of the Su(H) binding site leads to a significant reduction of brE reporter expression in follicle cells undergoing the endocycle. Chromatin immunoprecipitation results further confirm Su(H) binding to the br early enhancer. Consistent with its expression in follicle cells during midoogenesis, loss of br function results in a delayed entry into the endocycle. Our findings suggest an important role of br in the timing of follicle cell development, and its transcriptional regulation by the Notch pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.