ArticleOrganic letters2014
Cycloheximide and actiphenol production in Streptomyces sp. YIM56141 governed by single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase.
Article in Organic letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 52 citations in OpenAlex.
- Research progress of glutarimide-containing polyketides: Structures, bioactivities and their biosynthesis.Pharmaceutical science advances · 2025Review
- ThiF-Like Enzyme Chemistry in Primary and Secondary Metabolism.Chembiochem : a European journal of chemical biology · 2025Review
- Cytotoxic glutarimide-containing polyketides isolated from Streptomyces sp. JCM 4793.The Journal of antibiotics · 2024Article
- The Genomic-Driven Discovery of Glutarimide-Containing Derivatives fromMolecules (Basel, Switzerland) · 2023Article
- Co-Expression of Transcriptional Regulators and Housekeeping Genes inMicroorganisms · 2023Article
- Production of secondary metabolites in stirred tank bioreactor co-cultures ofFrontiers in bioengineering and biotechnology · 2022Article
- Exploration of Diverse Secondary Metabolites FromFrontiers in microbiology · 2022Article
- Initiating polyketide biosynthesis by on-line methyl esterification.Nature communications · 2021Article
- Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria.Nature communications · 2021Article
- Bacterial Quorum-Sensing Molecules as Promising Natural Inhibitors ofFrontiers in cellular and infection microbiology · 2021Article
- Insect-Associated Bacteria Assemble the Antifungal Butenolide Gladiofungin by Non-Canonical Polyketide Chain Termination.Angewandte Chemie (International ed. in English) · 2020Article
- Genomics-Driven Discovery of a Novel Glutarimide Antibiotic from Burkholderia gladioli Reveals an Unusual Polyketide Synthase Chain Release Mechanism.Angewandte Chemie (International ed. in English) · 2020Article
- Isolation of new streptimidone derivatives, glutarimide antibiotics from Streptomyces sp. W3002 using LC-MS-guided screening.The Journal of antibiotics · 2020Article
- Article
- Cycloheximide-ProducingFrontiers in microbiology · 2020Article
- Leveraging a large microbial strain collection for natural product discovery.The Journal of biological chemistry · 2019Review
- Article
- Promoter Engineering Reveals the Importance of Heptameric Direct Repeats for DNA Binding by Streptomyces Antibiotic Regulatory Protein-Large ATP-Binding Regulator of the LuxR Family (SARP-LAL) Regulators in Streptomyces natalensis.Applied and environmental microbiology · 2018Article
- A Long-Range Acting Dehydratase Domain as the Missing Link for C17-Dehydration in Iso-Migrastatin Biosynthesis.Angewandte Chemie (International ed. in English) · 2017Article
- Biogenesis of antibiotics-viewing its history and glimpses of the future.Folia microbiologica · 2016Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Cycloheximide (1) and actiphenol (2) have been isolated from numerous Streptomyces species. Cloning, sequencing, and characterization of a gene cluster from Streptomyces sp. YIM65141 now establish that 1 and 2 production is governed by single biosynthetic machinery. Biosynthesis of 1 features an acyltransferase-less type I polyketide synthase to construct its carbon backbone but may proceed via 2 as a key intermediate, invoking a provocative reduction of a phenol to a cyclohexanone moiety in natural product biosynthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.