Evidence map›Paper›PMID 24814566›Full record

Trial reportDrug and alcohol dependence2014

Modulation of smoking and decision-making behaviors with transcranial direct current stimulation in tobacco smokers: a preliminary study.

Shirley Fecteau, Sara Agosta, Antoine Hone-Blanchet, Felipe Fregni, Paulo Boggio, Domenic Ciraulo, Alvaro Pascual-Leone

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug and alcohol dependence, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 71 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02178852 phase1 / phase2unknown statusnot on this map

Effect of Trigeminal Nerve Stimulation (TNS) on Nicotine Craving: Phase II, Cross-over, Randomized, Sham-controlled Clinical Trial

TypeinterventionalSponsorSanta Casa Medical SchoolRan2014Enrolled22ConditionsNicotine CravingArmsTRIGEMINAL NERVE STIMULATION (TNS)
NCT04432064 naterminatednot on this mapstarted 2020, after this paper: background citation

Temporal Interference Neurostimulation and Addiction

TypeinterventionalSponsorIndiana UniversityRan2020 to 2022Enrolled10ConditionsNicotine Use Disorder, Substance Use DisordersArmsActive TI-NDBS, Sham TI-NDBS, tDCS
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. A systematic review and meta-analysis of neuromodulation therapies for substance use disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
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  3. A Systematic Review of Noninvasive Brain Stimulation for Opioid Use Disorder.Neuromodulation : journal of the International Neuromodulation Society · 2020
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shirley FecteauLaboratory of Canada Research Chair in Cognitive Neuroscience, Centre Interdisciplinaire de Recherche en Réadaptation et Intégration Sociale, Centre de Recherche l'Institut Universitaire en Santé Mentale de Québec, Medical School, Laval University, Québec, QC, Canada; Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address: Shirley.fecteau@fmed.ulaval.ca.
Sara AgostaBerenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Center for Neuroscience and Cognitive Systems@UniTn, Italian Institute of Technology, Rovereto, Italy.
Antoine Hone-BlanchetLaboratory of Canada Research Chair in Cognitive Neuroscience, Centre Interdisciplinaire de Recherche en Réadaptation et Intégration Sociale, Centre de Recherche l'Institut Universitaire en Santé Mentale de Québec, Medical School, Laval University, Québec, QC, Canada.
Felipe FregniBerenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Laboratory of Neuromodulation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, USA.
Paulo BoggioNúcleo de Neurociências, Centro de Ciências Biológicas e da Saúde, Universidade Presbiteriana Mackenzie, São Paulo, SP, Brazil.
Domenic CirauloBoston University School of Medicine, Boston Medical Center, Boston, MA, USA.
Alvaro Pascual-LeoneBerenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Institut Guttmann de Neurorehabilitació, Universitat Autónoma, Barcelona, Spain.

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
ZD6416 Analgesic--Painful Distal Symmetrical PolyneuropaM01RR001066 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, EMERY N · 1985 to 2008
$37.4M
Study and Modulation of Brian PlasticityK24RR018875 · NCRR · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PASCUAL-LEONE, ALVARO · 2004 to 2008
$602k
CIHRNCRR NIH HHS K24 RR018875NCRR NIH HHS K24RR018875NCRR NIH HHS M01-RR-01066NCRR NIH HHS UL1 RR025758NCRR NIH HHS UL1RR025758
6 · The paper itself

Abstract

backgroundMost tobacco smokers who wish to quit fail to reach their goal. One important, insufficiently emphasized aspect of addiction relates to the decision-making system, often characterized by dysfunctional cognitive control and a powerful drive for reward. Recent proof-of-principle studies indicate that transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) can transiently modulate processes involved in decision-making, and reduce substance intake and craving for various addictions. We previously proposed that this beneficial effect of stimulation for reducing addictive behaviors is in part mediated by more reflective decision-making. The goal of this study was to test whether nicotine intake and decision-making behaviors are modulated by tDCS over the DLPFC in tobacco smokers who wished to quit smoking.

methodsSubjects received two five-day tDCS regimens (active or sham). Stimulation was delivered over the right DLPFC at a 2 mA during 30 min. Nicotine cravings, cigarette consumption and decision-making were assessed before and after each session.

resultsMain findings include a significant decrease in the number of cigarettes smoked when participants received active as compared to sham stimulation. This effect lasted up to four days after the end of the stimulation regimen. In regards to decision-making, smokers rejected more often offers of cigarettes, but not offers of money, after they received active as compared to sham stimulation at the Ultimatum Game. No significant change was observed at the Risk Task with cigarettes or money as rewards.

conclusionOverall, these findings suggest that tDCS over the DLPFC may be beneficial for smoking reduction and induce reward sensitive effects.

Indexed as

Decision MakingTranscranial Direct Current StimulationAdultCarbon MonoxideCross-Over StudiesDouble-Blind MethodFemaleGames, ExperimentalHumansMaleMiddle AgedPrefrontal CortexRewardRisk-TakingSmokingYoung AdultCarbon MonoxideAddictionDecision-makingNoninvasive brain stimulationTobacco

Identifiers

PMID24814566
PMCPMC4242508

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.