Evidence map›Paper›PMID 24814487›Full record

ReviewJournal of the American College of Cardiology2014

Headed in the right direction but at risk for miscalculation: a critical appraisal of the 2013 ACC/AHA risk assessment guidelines.

Nivee P Amin, Seth S Martin, Michael J Blaha, Khurram Nasir, Roger S Blumenthal, Erin D Michos

Open access · greenAbstract readReview
In one paragraph

Review in Journal of the American College of Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 71 citations in OpenAlex.

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  15. Cardiovascular Risk Prediction in Korean Adults.Korean journal of family medicine · 2018
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nivee P AminCiccarone Center for the Prevention of Cardiovascular Diseases, Johns Hopkins University, Baltimore, Maryland.
Seth S MartinCiccarone Center for the Prevention of Cardiovascular Diseases, Johns Hopkins University, Baltimore, Maryland.
Michael J BlahaCiccarone Center for the Prevention of Cardiovascular Diseases, Johns Hopkins University, Baltimore, Maryland.
Khurram NasirCiccarone Center for the Prevention of Cardiovascular Diseases, Johns Hopkins University, Baltimore, Maryland; Center for Wellness & Prevention Research, Baptist Health Medical Group, Miami Beach, Florida.
Roger S BlumenthalCiccarone Center for the Prevention of Cardiovascular Diseases, Johns Hopkins University, Baltimore, Maryland.
Erin D MichosCiccarone Center for the Prevention of Cardiovascular Diseases, Johns Hopkins University, Baltimore, Maryland. Electronic address: edonnell@jhmi.edu.
Johns Hopkins University · USBaptist Hospital of Miami · US

Funding

PATHOPHYSIOLOGY OF MYOCARDIAL DISEASEST32HL007227 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Chulan Kwon, WENDY S POST · 1985 to 2026
$21.2M
CARDIOVASCULAR EPIDEMIOLOGY INSTITUTIONAL TRAININGT32HL007024 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Elizabeth Selvin · 1985 to 2026
$17.5M
NHLBI NIH HHS T32 HL007024NHLBI NIH HHS T32 HL007227
6 · The paper itself

Abstract

The newly released 2013 ACC/AHA Guidelines for Assessing Cardiovascular Risk makes progress compared with previous cardiovascular risk assessment algorithms. For example, the new focus on total atherosclerotic cardiovascular diseases (ASCVD) is now inclusive of stroke in addition to hard coronary events, and there are now separate equations to facilitate estimation of risk in non-Hispanic white and black individuals and separate equations for women. Physicians may now estimate lifetime risk in addition to 10-year risk. Despite this progress, the new risk equations do not appear to lead to significantly better discrimination than older models. Because the exact same risk factors are incorporated, using the new risk estimators may lead to inaccurate assessment of atherosclerotic cardiovascular risk in special groups such as younger individuals with unique ASCVD risk factors. In general, there appears to be an overestimation of risk when applied to modern populations with greater use of preventive therapy, although the magnitude of overestimation remains unclear. Because absolute risk estimates are directly used for treatment decisions in the new cholesterol guidelines, these issues could result in overuse of pharmacologic management. The guidelines could provide clearer direction on which individuals would benefit from additional testing, such as coronary calcium scores, for more personalized preventive therapies. We applaud the advances of these new guidelines, and we aim to critically appraise the applicability of the risk assessment tools so that future iterations of the estimators can be improved to more accurately assess risk in individual patients.

Indexed as

Cardiovascular DiseasesAlgorithmsGlobal HealthHumansIncidencePractice Guidelines as TopicRetrospective StudiesRisk AssessmentRisk Factorscoronary artery calciumguidelinespreventive cardiologyrisk assessment

Identifiers

PMID24814487
PMCPMC4280905
OpenAlexW1570847954

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.