ArticleMechanisms of ageing and development2014
Relationship between heat shock protein 70 expression and life span in Daphnia.
Article in Mechanisms of ageing and development, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Protein homeostasis in aging and cancer.Frontiers in cell and developmental biology · 2023Review
- HSPA6 and its role in cancers and other diseases.Molecular biology reports · 2022Review
- Relationship between oxidative stress and lifespan in Daphnia pulex.Scientific reports · 2022Article
- Short-term heat shock perturbation affects populations of Daphnia magna and Eurytemora carolleeae: a warning to the water thermal pollution.Scientific reports · 2021Article
- A chromosome-level assembly of the black tiger shrimp (Penaeus monodon) genome facilitates the identification of growth-associated genes.Molecular ecology resources · 2021Article
- Distinct Gene Expression Patterns of Two Heat Shock Protein 70 Members During Development, Diapause, and Temperature Stress in the Freshwater CrustaceanFrontiers in cell and developmental biology · 2021Article
- A comprehensive epigenomic analysis of phenotypically distinguishable, genetically identical female and male Daphnia pulex.BMC genomics · 2020Article
- Resurrected 'ancient'Royal Society open science · 2018Article
- Population Genomics ofGenetics · 2017Article
- Effects of fluctuating temperature and food availability on reproduction and lifespan.Experimental gerontology · 2016Article
- The molecular chaperone Hsp70 promotes the proteolytic removal of oxidatively damaged proteins by the proteasome.Free radical biology & medicine · 2016Article
- Article
- Exogenous Hsp70 delays senescence and improves cognitive function in aging mice.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Development of an efficient RNA interference method by feeding for the microcrustacean Daphnia.BMC biotechnology · 2015Article
- Invertebrates as model organisms for research on aging biology.Invertebrate reproduction & development · 2015Article
- Telomerase activity and telomere length in Daphnia.PloS one · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The longevity of an organism is directly related to its ability to effectively cope with cellular stress. Heat shock response (HSR) protects the cells against accumulation of damaged proteins after exposure to elevated temperatures and also in aging cells. To understand the role of Hsp70 in regulating life span of Daphnia, we examined the expression of Hsp70 in two ecotypes that exhibit strikingly different life spans. Daphnia pulicaria, the long lived ecotype, showed a robust Hsp70 induction as compared to the shorter lived Daphnia pulex. Interestingly, the short-lived D. pulex isolates showed no induction of Hsp70 at the mid point in their life span. In contrast to this, the long-lived D. pulicaria continued to induce Hsp70 expression at an equivalent age. We further show that the Hsp70 expression was induced at transcriptional level in response to heat shock. The transcription factor responsible for Hsp70 induction, heat shock factor-1 (HSF-1), although present in aged organisms did not exhibit DNA-binding capability. Thus, the decline of Hsp70 induction in old organisms could be attributed to a decline in HSF-1's DNA-binding activity. These results for the first time, present a molecular analysis of the relationship between HSR and life span in Daphnia.
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