ArticleCurrent biology : CB2014
Local control of intestinal stem cell homeostasis by enteroendocrine cells in the adult Drosophila midgut.
Article in Current biology : CB, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 101 citations in OpenAlex.
- Sex-biased expression of enteroendocrine cell-derived hormones contributes to higher fat storage ineLife · 2026Article
- A Tale of Two States: Similarities and Differences in Neuropeptide Signaling in Larval and Adult Drosophila.The Journal of comparative neurology · 2026Review
- Intestinal epithelial cells in health and disease.Tissue barriers · 2026Review
- The gut-kidney axis in high-altitude hypoxia: pathophysiological mechanisms and the central role of hypoxia inducible factor.Annals of medicine · 2025Review
- Gut-brain communication in Drosophila melanogaster.Current opinion in neurobiology · 2025Review
- Regulatory Mechanism of Intestinal Stem Cells Based on Hippo Pathway and Signaling Crosstalk in Chicken.International journal of molecular sciences · 2025Review
- Alternate Grainy head isoforms regulate Drosophila midgut intestinal stem cell differentiation.Cell death discovery · 2025Article
- Gut-Brain Dialogues in Fruit Fly (Current drug targets · 2025Review
- Drosophila Intestine as a Model to Study Tumors.Advances in experimental medicine and biology · 2025Review
- Article
- Review
- Enteroendocrine cells regulate intestinal homeostasis and epithelial function.Molecular and cellular endocrinology · 2024Review
- Gut-to-brain regulation ofProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Gut-to-brain regulation ofbioRxiv : the preprint server for biology · 2024Article
- TrpA1 is a shear stress mechanosensing channel regulating intestinal stem cell proliferation inScience advances · 2023Article
- Enteroendocrine cells and gut hormones as potential targets in the crossroad of the gut-kidney axis communication.Frontiers in pharmacology · 2023Review
- Neuropeptide hormone bursicon mediates female reproduction in the whitefly,Frontiers in endocrinology · 2023Article
- Review
- Expression analysis of peptidergic enteroendocrine cells in the silkworm Bombyx mori.Cell and tissue research · 2022Article
- Wear and tear of the intestinal visceral musculature by intrinsic and extrinsic factors.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundEnteroendocrine cells populate gastrointestinal tissues and are known to translate local cues into systemic responses through the release of hormones into the bloodstream.
resultsHere we report a novel function of enteroendocrine cells acting as local regulators of intestinal stem cell (ISC) proliferation through modulation of the mesenchymal stem cell niche in the Drosophila midgut. This paracrine signaling acts to constrain ISC proliferation within the epithelial compartment. Mechanistically, midgut enteroendocrine cells secrete the neuroendocrine hormone Bursicon, which acts-beyond its known roles in development-as a paracrine factor on the visceral muscle (VM). Bursicon binding to its receptor, DLGR2, the ortholog of mammalian leucine-rich repeat-containing G protein-coupled receptors (LGR4-6), represses the production of the VM-derived EGF-like growth factor Vein through activation of cAMP.
conclusionsWe therefore identify a novel paradigm in the regulation of ISC quiescence involving the conserved ligand/receptor Bursicon/DLGR2 and a previously unrecognized tissue-intrinsic role of enteroendocrine cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.