ArticleThe American journal of pathology2014
IL-19 reduces ligation-mediated neointimal hyperplasia by reducing vascular smooth muscle cell activation.
Article in The American journal of pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 33 citations in OpenAlex.
- Toll-like receptor 2 and 4 induced interleukin-19 dampens immune reactions and associates inversely with spondyloarthritis disease activity.Clinical and experimental immunology · 2015Trial
- IL-19 Is a Novel Lymphangiocrine Factor Inducing Lymphangiogenesis and Lymphatic Junctional Regulation.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Cytokines are the Basis of the Development and Suppression of Inflammation in Atherosclerosis.Reviews in cardiovascular medicine · 2025Review
- A Multi-Machine Learning Consensus Model Based on Clinical Features Reveals That Interleukin-10 Derived from Monocytes Leads to a Poor Prognosis in Patients with Coronavirus Disease-2019.Journal of inflammation research · 2024Article
- Genetic Deletion of FXR1 Reduces Intimal Hyperplasia and Induces Senescence in Vascular Smooth Muscle Cells.The American journal of pathology · 2023Article
- Stress decreases contraction of the colon, and the effects of stress are different among the regions of the colon.The Journal of veterinary medical science · 2022Article
- Recombinant Interleukin-19 Suppresses the Formation and Progression of Experimental Abdominal Aortic Aneurysms.Journal of the American Heart Association · 2021Article
- Gastrointestinal motility modulation by stress is associated with reduced smooth muscle contraction through specific transient receptor potential channel.The Journal of veterinary medical science · 2021Article
- Interleukin-19 Abrogates Experimental Autoimmune Encephalomyelitis by Attenuating Antigen-Presenting Cell Activation.Frontiers in immunology · 2021Article
- Interleukin-19 enhances cytokine production induced by lipopolysaccharide and inhibits cytokine production induced by polyI:C in BALB/c mice.The Journal of veterinary medical science · 2020Article
- Endothelial cell-derived extracellular vesicles alter vascular smooth muscle cell phenotype through high-mobility group box proteins.Journal of extracellular vesicles · 2020Article
- Regulation of Stress Granule Formation by Inflammation, Vascular Injury, and Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2019Article
- FXR1 Is an IL-19-Responsive RNA-Binding Protein that Destabilizes Pro-inflammatory Transcripts in Vascular Smooth Muscle Cells.Cell reports · 2018Article
- Treatment with IL-19 improves locomotor functional recovery after contusion trauma to the spinal cord.British journal of pharmacology · 2018Article
- Genetic Deletion of IL-19 (Interleukin-19) Exacerbates Atherogenesis inArteriosclerosis, thrombosis, and vascular biology · 2018Article
- Candida albicans β-Glucan-Containing Particles Increase HO-1 Expression in Oral Keratinocytes via a Reactive Oxygen Species/p38 Mitogen-Activated Protein Kinase/Nrf2 Pathway.Infection and immunity · 2018Article
- IL-19 and Other IL-20 Family Member Cytokines in Vascular Inflammatory Diseases.Frontiers in immunology · 2018Review
- Induction of MiR133a expression by IL-19 targets LDLRAP1 and reduces oxLDL uptake in VSMC.Journal of molecular and cellular cardiology · 2017Article
- The association between interleukin-19 concentration and diabetic nephropathy.BMC nephrology · 2017Article
- The Role of Cytokines in the Development of Atherosclerosis.Biochemistry. Biokhimiia · 2016Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
We tested the hypothesis that IL-19, a putative member of the type 2 helper T-cell family of anti-inflammatory interleukins, can attenuate intimal hyperplasia and modulate the vascular smooth muscle cell (VSMC) response to injury. Ligated carotid artery of IL-19 knockout (KO) mice demonstrated a significantly higher neointima/intima ratio compared with wild-type (WT) mice (P = 0.04). More important, the increased neointima/intima ratio in the KO could be reversed by injection of 10 ng/g per day recombinant IL-19 into the KO mouse (P = 0.04). VSMCs explanted from IL-19 KO mice proliferated significantly more rapidly than WT. This could be inhibited by addition of IL-19 to KO VSMCs (P = 0.04 and P < 0.01). IL-19 KO VSMCs migrated more rapidly compared with WT (P < 0.01). Interestingly, there was no type 1 helper T-cell polarization in the KO mouse, but there was significantly greater leukocyte infiltrate in the ligated artery in these mice compared with WT. IL-19 KO VSMCs expressed significantly greater levels of inflammatory mRNA, including IL-1β, tumor necrosis factor α, and monocyte chemoattractant protein-1 in response to tumor necrosis factor α stimulation (P < 0.01 for all). KO VSMCs expressed greater adhesion molecule expression and adherence to monocytes. Together, these data indicate that IL-19 is a previously unrecognized counterregulatory factor for VSMCs, and its expression is an important protective mechanism in regulation of vascular restenosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.