ArticleJournal of the American Medical Directors Association2014
Determining the incidence of drug-associated acute kidney injury in nursing home residents.
Article in Journal of the American Medical Directors Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01531088 (Enhancing the Detection and Management of Adverse Drug Events in the Nursing Home), which is not on this map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Enhancing the Detection and Management of Adverse Drug Events in the Nursing Home
Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Physician Perceptions of Consultant Pharmacist Services Associated with an Intervention for Adverse Drug Events in the Nursing Facility.The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists · 2016Trial
- Medication Holds in CKD During Acute Volume-Depleting Illnesses: A Randomized Controlled Trial of a "Sick-Day" Protocol.Kidney medicine · 2022Article
- Risk factors for and characteristics of community- and hospital-acquired drug-induced acute kidney injuries.Fundamental & clinical pharmacology · 2022Article
- The clinicopathological features of drug-induced acute kidney injury-a single-center retrospective analysis.Annals of translational medicine · 2021Article
- Hypertension Treatment in US Long-Term Nursing Home Residents With and Without Dementia.Journal of the American Geriatrics Society · 2019Observational
- Application of prescribing recommendations in older people with reduced kidney function: a cross-sectional study in general practice.The British journal of general practice : the journal of the Royal College of General Practitioners · 2018Article
- Drug management in acute kidney disease - Report of the Acute Disease Quality Initiative XVI meeting.British journal of clinical pharmacology · 2018Article
- Combined use of drugs inhibiting the renin-angiotensin system: prescribing patterns and risk of acute kidney injury in German nursing home residents.Clinical interventions in aging · 2018Article
- The drugs that mostly frequently induce acute kidney injury: a case - noncase study of a pharmacovigilance database.British journal of clinical pharmacology · 2017Article
- Hospital Transfers of Skilled Nursing Facility (SNF) Patients Within 48 Hours and 30 Days After SNF Admission.Journal of the American Medical Directors Association · 2016Article
- Impact of electronic-alerting of acute kidney injury: workgroup statements from the 15(th) ADQI Consensus Conference.Canadian journal of kidney health and disease · 2016Review
- Cumulative Cardiovascular Polypharmacy Is Associated With the Risk of Acute Kidney Injury in Elderly Patients.Medicine · 2015Observational
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7 authors at 1 institution in 1 country.
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Abstract
objectiveAlthough acute kidney injury (AKI) is well studied in the acute care setting, investigation of AKI in the nursing home (NH) setting is virtually nonexistent. The goal of this study was to determine the incidence of drug-associated AKI using the RIFLE (Risk, Injury, Failure, Loss of kidney function, or End-Stage kidney disease) criteria in NH residents. DESIGN/SETTING/PARTICIPANTS/MEASUREMENTS: We conducted a retrospective study between February 9, 2012, and February 8, 2013, for all residents at 4 UPMC NHs located in southwest Pennsylvania. The TheraDoc™ Clinical Surveillance Software System, which monitors laboratory and medication data and fires alerts when patients have a sufficient increase in serum creatinine, was used for automated case detection. An increase in serum creatinine in the presence of an active medication order identified to potentially cause AKI triggered an alert, and drug-associated AKI was staged according to the RIFLE criteria. Data were analyzed by frequency and distribution of alert type by risk, injury, and failure.
resultsOf the 249 residents who had a drug-associated AKI alert fire, 170 (68.3%) were women, and the mean age was 74.2 years. Using the total number of alerts (n = 668), the rate of drug-associated AKI was 0.41 events per 100 resident-days. Based on the RIFLE criteria, there were 191, 70, and 44 residents who were classified as AKI risk, injury, and failure, respectively. The most common medication classes included in the AKI alerts were diuretics, angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers (ACEIs/ARBs), and antibiotics.
conclusionDrug-associated AKI was a common cause of potential adverse drug events. The vast majority of cases were related to the use of diuretics, ACEIs/ARBs, and antibiotics. Future studies are needed to better understand patient, provider, and facility risk factors, as well as strategies to enhance the detection and management of drug-associated AKI in the NH.
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