ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2014
Complex prosthetic joint infections due to carbapenemase-producing Klebsiella pneumoniae: a unique challenge in the era of untreatable infections.
Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Resistance of different antimicrobials to CRKP: a meta analysis.BMC infectious diseases · 2026Pooled it
- Triple combination antibiotic therapy for carbapenemase-producing Klebsiella pneumoniae: a systematic review.Annals of clinical microbiology and antimicrobials · 2017Pooled it
- [Antimicrobial therapy of periprosthetic joint infection : Full version of the AE guidelines (2026)].Orthopadie (Heidelberg, Germany) · 2026Review
- Convergent methodologies in prosthetic joint infection research: integrating transdisciplinary approaches to understand and prevent biofilm-driven failure of orthopaedic prostheses.Journal of medical microbiology · 2026Review
- Efficacy and Safety of Tetracyclines in Bone and Joint Infections: A Literature Review.Infectious diseases and therapy · 2026Review
- The Role of PositivePathogens (Basel, Switzerland) · 2026Article
- Tribological and antibacterial behavior of Cu doped DLC coatings for biomedical implants.Discover materials · 2026Article
- Antimicrobial Treatment Options for Multidrug Resistant Gram-Negative Pathogens in Bone and Joint Infections.Pathogens (Basel, Switzerland) · 2025Review
- Effect of novel antimicrobial blue light-emitting optical fiber on vancomycin-resistantJournal of bone and joint infection · 2025Article
- Comprehensive analysis of the pathogen spectrum and antibiotic resistance profiles in periprosthetic joint infections: a single center retrospective study.Frontiers in surgery · 2025Article
- Effective phage cocktail to combat the rising incidence of extensively drug-resistantEmerging microbes & infections · 2022Article
- Salvaging lives in carbapenem-resistant Gram-negative osteoarticular and soft tissue infections: early compromises save lives.International orthopaedics · 2022Article
- Trends in microbiological profiles and antibiotic resistance in periprosthetic joint infections.The Journal of international medical research · 2021Article
- Prevention and Killing Efficacy of Carbapenem ResistantMaterials (Basel, Switzerland) · 2020Article
- Tigecycline Versus Colistin in the Treatment of Carbapenem-resistantJournal of bone and joint infection · 2020Article
- Orthopedic Implant-Associated Infection by Multidrug ResistantJournal of clinical medicine · 2019Article
- Clinical Experience with Tigecycline in the Treatment of Prosthetic Joint Infections.Journal of bone and joint infection · 2019Article
- Prosthetic Joint Infection from Carbapenemase-ResistantCase reports in infectious diseases · 2018Article
- Treatment of Prosthetic Joint Infection with Debridement, Antibiotics and Irrigation with Implant Retention - a Narrative Review.Journal of bone and joint infection · 2018Review
- Failure of the first step of two-stage revision due to polymicrobial prosthetic joint infection of the hip.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2016Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
Abstract
objectivesLimited clinical experience exists regarding the management of prosthetic joint infection (PJI) due to multidrug-resistant (MDR) Gram-negative organisms. We review three cases of carbapenem-resistant Klebsiella pneumoniae (CRKP) complicating PJI.
methodsThis was a retrospective study of all patients at a tertiary care institution with CRKP complicating PJI between January 2007 and December 2010. Demographic data, procedures, organisms involved, length of stay, antibiotic treatments, and outcomes were collected. Antimicrobial susceptibility testing was performed on CRKP isolates, and the mechanism of resistance was ascertained by PCR.
resultsThis analysis demonstrated that: (1) the CRKP possessed blaKPC and were difficult to eradicate (persistent) in PJI; (2) multiple surgeries and antibiotic courses were undertaken and patients required a prolonged length of stay; (3) resistance to colistin and amikacin emerged on therapy; (4) the same strain of CRKP may be responsible for relapse of infection; (5) significant morbidity and mortality resulted.
conclusionsThese cases highlight the opportunistic and chronic nature of CRKP in PJIs and the need for aggressive medical and surgical treatment. Further investigations of the management of CRKP PJI and new drug therapies for infections due to MDR Gram-negative organisms are urgently needed.
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