Trial reportActa paediatrica (Oslo, Norway : 1992)2014
A randomised controlled trial of an automated oxygen delivery algorithm for preterm neonates receiving supplemental oxygen without mechanical ventilation.
Trial report in Acta paediatrica (Oslo, Norway : 1992), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Automated oxygen delivery for preterm infants with respiratory dysfunction.The Cochrane database of systematic reviews · 2023Pooled it
- Eligibility Criteria and Representativeness of Randomized Clinical Trials That Include Infants Born Extremely Premature: A Systematic Review.The Journal of pediatrics · 2021Pooled it
- Automated versus manual control of inspired oxygen to target oxygen saturation in preterm infants: a systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2018Pooled it
- Compliance in oxygen saturation targeting in preterm infants: a systematic review.European journal of pediatrics · 2015Pooled it
- Automated oxygen control versus manual titration in preterm infants: A systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Closed-Loop Automated Oxygen Control in Preterm Infants Receiving Non-Invasive Respiratory Support.Children (Basel, Switzerland) · 2025Review
- Closed-loop oxygen usage during invasive mechanical ventilation of pediatric patients (CLOUDIMPP): a randomized controlled cross-over study.Frontiers in medicine · 2024Article
- Clinical Evaluation of an Automatic Oxygen Control System for Premature Infants Receiving High-Flow Nasal Cannula for Respiratory Support: A Pilot Study.Journal of medical devices · 2022Article
- Automated Oxygen Delivery in Neonatal Intensive Care.Frontiers in pediatrics · 2022Review
- Closed-loop oxygen control improves oxygenation in pediatric patients under high-flow nasal oxygen-A randomized crossover study.Frontiers in medicine · 2022Article
- Continuous vital sign analysis for predicting and preventing neonatal diseases in the twenty-first century: big data to the forefront.Pediatric research · 2020Review
- Continuous pulse oximetry and respiratory rate trends predict short-term respiratory and growth outcomes in premature infants.Pediatric research · 2019Article
- Pulse oximetry values of neonates admitted for care and receiving routine oxygen therapy at a resource-limited hospital in Kenya.Journal of paediatrics and child health · 2018Article
- Hypoxic events and concomitant factors in preterm infants on non-invasive ventilation.Journal of clinical monitoring and computing · 2017Article
- A model for oxygen conservation associated with titration during pediatric oxygen therapy.PloS one · 2017Article
- Improving manual oxygen titration in preterm infants by training and guideline implementation.European journal of pediatrics · 2017Observational
- Oxygen Use in Neonatal Care: A Two-edged Sword.Frontiers in pediatrics · 2016Review
- Safe oxygen saturation targeting and monitoring in preterm infants: can we avoid hypoxia and hyperoxia?Acta paediatrica (Oslo, Norway : 1992) · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimProviding consistent levels of oxygen saturation (SpO2 ) for infants in neonatal intensive care units is not easy. This study explored how effectively the Auto-Mixer(®) algorithm automatically adjusted fraction of inspired oxygen (FiO2 ) levels to maintain SpO2 within an intended range in extremely low birth weight infants receiving supplemental oxygen without mechanical ventilation.
methodsTwenty extremely low birth weight infants were randomly assigned to the Auto-Mixer(®) group or the manual intervention group and studied for 12 h. The SpO2 target was 85-93%, and the outcomes were the percentage of time SpO2 was within target, SpO2 variability, SpO2 >95%, oxygen received and manual interventions.
resultsThe percentage of time within intended SpO2 was 58 ± 4% in the Auto-Mixer(®) group and 33.7 ± 4.7% in the manual group, SpO2 >95% was 26.5% vs 54.8%, average SpO2 and FiO2 were 89.8% vs 92.2% and 37% vs 44.1%, and manual interventions were 0 vs 80 (p < 0.05). Brief periods of SpO2 < 85% occurred more frequently in the Auto-Mixer(®) group.
conclusionThe Auto-Mixer(®) effectively increased the percentage of time that SpO2 was within the intended target range and decreased the time with high SpO2 in spontaneously breathing extremely low birth weight infants receiving supplemental oxygen.
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