ArticlePhysiology & behavior2014
Genetic deletion of the MT1 or MT2 melatonin receptors abrogates methamphetamine-induced reward in C3H/HeN mice.
Article in Physiology & behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Adrenal MTHormones and behavior · 2022Article
- Mice lacking melatonin MT2 receptors exhibit attentional deficits, anxiety and enhanced social interaction.Journal of psychopharmacology (Oxford, England) · 2021Article
- Melatonin Blocks Morphine-Induced Place Preference: Involvement of GLT-1, NF-κB, BDNF, and CREB in the Nucleus Accumbens.Frontiers in behavioral neuroscience · 2021Article
- CRISPR/Cas9 mediated mutation of the mtnr1a melatonin receptor gene causes rod photoreceptor degeneration in developing Xenopus tropicalis.Scientific reports · 2020Article
- Differential genetic risk for methamphetamine intake confers differential sensitivity to the temperature-altering effects of other addictive drugs.Genes, brain, and behavior · 2020Article
- Inhibitory effects of Shati/Nat8l overexpression in the medial prefrontal cortex on methamphetamine-induced conditioned place preference in mice.Addiction biology · 2020Article
- Melatonin in drug addiction and addiction management: Exploring an evolving multidimensional relationship.World journal of psychiatry · 2018Review
- Food-induced reinforcement is abrogated by the genetic deletion of the MTBehavioural brain research · 2018Article
- The muscarinic effect of anhydroecgonine methyl ester, a crack cocaine pyrolysis product, impairs melatonin synthesis in the rat pineal gland.Toxicology research · 2017Article
- Melatonin Secretion during a Short Nap Fosters Subsequent Feedback Learning.Frontiers in human neuroscience · 2017Article
- Learned motivation drives circadian physiology in the absence of the master circadian clock.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Update on melatonin receptors: IUPHAR Review 20.British journal of pharmacology · 2016Review
- MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective.Annual review of pharmacology and toxicology · 2016Review
- An animal model of differential genetic risk for methamphetamine intake.Frontiers in neuroscience · 2015Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
The drug of abuse methamphetamine (METH) is known for its ability to enhance reward responses. The rewarding properties of psychostimulants have been shown to vary across time of day in mice. The goal of this study was to determine the role of the MT1 and MT2 melatonin receptors in METH-induced reward, as measured by the conditioned place preference (CPP) paradigm during the light and dark phases. C3H/HeN wild-type mice were trained for METH-induced CPP at either ZT 6-8 (ZT: Zeitgeber time; ZT 0=lights on), when endogenous melatonin levels are low, or ZT 19-21, when melatonin levels are high. These time points also correspond to the high and low points for expression of the circadian gene Period1, respectively. The locomotor response to METH (1.2mg/kg, ip) treatment was of similar magnitude at both times; however only C3H/HeN mice conditioned to METH at ZT 6-8 developed a place preference. C3H/HeN mice with a genetic deletion of either the MT1 (MT1KO) or MT2 (MT2KO) receptor tested at ZT 6-8 or ZT 19-21 did not develop a place preference for METH, though both showed a similar increase in locomotor activity following METH treatment when compared to wild-type mice. We conclude that in our mouse model METH-induced CPP is dependent on time of day and the presence of the MT1 or MT2 receptors, suggesting a role for melatonin in METH-induced reward.
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