ArticleNature nanotechnology2014
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight.
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Article in Nature nanotechnology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 293 papers, 1 of them a synthesis that pooled it.
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293citing papers in PubMed, 1 pooled it
25.2field-weighted citation impact, top 1% of its field
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Who cites it
293 citing papers in PubMed, 1 synthesis or guideline pooled it, 568 citations in OpenAlex.
- RNA Drugs and RNA Targets for Small Molecules: Principles, Progress, and Challenges.Pharmacological reviews · 2020Pooled it
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- Endothelium-targeted and untargeted nanoparticle therapies in thromboinflammatory vascular diseases.Blood vessels, thrombosis & hemostasis · 2026Review
- Mechanisms and determinants of mRNALipid Nanoparticle biodistribution: From pharmacokinetics to clinical translation.Bioengineering & translational medicine · 2026Review
- Structural evolution of ionizable lipids for nucleic acid delivery.Nature reviews. Chemistry · 2026Review
- A TRAK2-KIF5B complex mediates microtubule-based LDL vesicle transport during endothelial transcytosis.Journal of lipid research · 2026Article
- Ligand-Mediated Reprogramming Redirects Liver-Tropic Ionizable Lipid Nanoparticles for Lung-Selective mRNA Delivery.Angewandte Chemie (International ed. in English) · 2026Article
- RNA delivery to the corneal endothelium using charge-altering releasable transporters.Science advances · 2026Article
- Delivery Systems for Therapeutic Genome Editing: Challenges, Innovations, and Future Perspectives.MedComm · 2026Review
- The RNA delivery dilemma-lipid versus polymer nanoparticle platforms.Drug delivery and translational research · 2026Article
- Influence of poly(styrene-co-maleic anhydride) molecular weight on nanoparticle-mediated drug delivery in breast cancer.Journal of translational medicine · 2026Article
- Lipid nanoparticle screening in nonhuman primates with minimal loss of life.Nature biotechnology · 2026Article
- Targeting PGC-1α by miRNA-374 Simultaneously Improve β-Cell Dysfunction and Suppress Hepatic Glucose Overproduction.Diabetes & metabolism journal · 2026Article
- Lipid nanoparticles for bone marrow-targeted RNA therapeutics.Journal of nanobiotechnology · 2026Review
- Delivery of mRNA Therapeutics Beyond Infectious Diseases: Design Innovations and Applications in Oncology, Cardiovascular, and Rare Genetic Diseases.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Lipid-based nanosystems for atherosclerosis treatment: Evolving approaches and novel therapeutic strategies.Acta pharmaceutica Sinica. B · 2026Review
- Multiplexed lipid nanoparticle barcoding reveals tissue-dynamic kinetic insights and enriched cellular tropism in hepatic zones.Nature communications · 2026Article
- Allele-selective von Willebrand factor silencing.Research and practice in thrombosis and haemostasis · 2026Article
- Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components.Small methods · 2026Review
- Payload-Driven Design of Polymeric Carriers for Nucleic Acid Delivery: Insights from Structure-Function Relationships.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
233 more citing papers are in PubMed but not listed here.
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Authors and funding
43 authors at 6 institutions in 3 countries.
James E Dahlman *Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Carmen Barnes *Alnylam Pharmaceuticals, Cambridge, Massachusetts 02139, USA.
Omar KhanDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Aude ThiriotDepartment of Microbiology and Immunology, Harvard Medical School, Boston 02115, USA.
Siddharth JhunjunwalaDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Taylor E ShawDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Yiping XingDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Hendrik B SagerCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA.
Gaurav SahayDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Lauren SpecinerAlnylam Pharmaceuticals, Cambridge, Massachusetts 02139, USA.
Andrew BaderDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Roman L BogoradDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Hao YinDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Tim RacieAlnylam Pharmaceuticals, Cambridge, Massachusetts 02139, USA.
Yizhou DongDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Shan JiangDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Danielle SeedorfDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Apeksha DaveDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Kamaljeet S SanduDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Matthew J WebberDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Tatiana NovobrantsevaAlnylam Pharmaceuticals, Cambridge, Massachusetts 02139, USA.
Vera M RudaDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Abigail K R Lytton-JeanDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Christopher G LevinsDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Brian KalishVascular Biology Program, Children's Hospital Boston, and Division of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston 02115, USA.
Dayna K MudgeVascular Biology Program, Children's Hospital Boston, and Division of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston 02115, USA.
Mario PerezProgram in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Program, Department of Medicine, University of Colorado School of Medicine, Aurora, USA.
Ludmila AbezgauzDeparment of Biotechnology and Food Engineering, and The Russell Berrie Nanotechnology Institute, Technion Israel Institute of Technology, Haifa 3200, Israel.
Partha DuttaCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA.
Lynelle SmithProgram in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Program, Department of Medicine, University of Colorado School of Medicine, Aurora, USA.
Klaus CharisseAlnylam Pharmaceuticals, Cambridge, Massachusetts 02139, USA.
Mark W KieranDepartment of Microbiology and Immunology, Harvard Medical School, Boston 02115, USA.
Kevin FitzgeraldAlnylam Pharmaceuticals, Cambridge, Massachusetts 02139, USA.
Matthias NahrendorfCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA.
Dganit DaninoDeparment of Biotechnology and Food Engineering, and The Russell Berrie Nanotechnology Institute, Technion Israel Institute of Technology, Haifa 3200, Israel.
Rubin M TuderProgram in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Program, Department of Medicine, University of Colorado School of Medicine, Aurora, USA.
Ulrich H von AndrianDepartment of Microbiology and Immunology, Harvard Medical School, Boston 02115, USA.
Akin AkincAlnylam Pharmaceuticals, Cambridge, Massachusetts 02139, USA.
Avi SchroederDepartment of Chemical Engineering, Technion Israel Institute of Technology, Haifa 32000, Israel.
Dipak PanigrahyDepartment of Microbiology and Immunology, Harvard Medical School, Boston 02115, USA.
Victor KotelianskiDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Robert LangerHarvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Daniel G AndersonHarvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Massachusetts Institute of Technology · USHarvard University · USAlnylam Pharmaceuticals (United States) · USHarvard–MIT Division of Health Sciences and Technology · USTechnion – Israel Institute of Technology · ILSkolkovo Institute of Science and Technology · RU
Funding
VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Michael Birnbaum · 1985 to 2026
$93.9MT Cell Activation in Lymph NodesR01AI069259 · NIAID · IMMUNE DISEASE INSTITUTE, INC. · PI VON ANDRIAN, ULRICH H · 2006 to 2015
$4.5MControl of cancer and metastasis by endothelial-derived epoxyeicosatrienoic acidsR01CA148633 · NCI · BOSTON CHILDREN'S HOSPITAL · PI PANIGRAHY, DIPAK · 2010 to 2014
$1.4MNCI NIH HHS P30 CA014051NCI NIH HHS R01 CA148633NCI NIH HHS R01 CA148663NIAID NIH HHS R01 AI069259
Abstract
Dysfunctional endothelium contributes to more diseases than any other tissue in the body. Small interfering RNAs (siRNAs) can help in the study and treatment of endothelial cells in vivo by durably silencing multiple genes simultaneously, but efficient siRNA delivery has so far remained challenging. Here, we show that polymeric nanoparticles made of low-molecular-weight polyamines and lipids can deliver siRNA to endothelial cells with high efficiency, thereby facilitating the simultaneous silencing of multiple endothelial genes in vivo. Unlike lipid or lipid-like nanoparticles, this formulation does not significantly reduce gene expression in hepatocytes or immune cells even at the dosage necessary for endothelial gene silencing. These nanoparticles mediate the most durable non-liver silencing reported so far and facilitate the delivery of siRNAs that modify endothelial function in mouse models of vascular permeability, emphysema, primary tumour growth and metastasis.
Indexed as
RNA InterferenceAnimalsCell LineEndothelial CellsHumansMiceNanoparticlesNeoplasmsPolymersRNA, Small InterferingPolymersRNA, Small Interfering
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