Evidence map›Paper›PMID 24813431›Full record

ArticleNeuroscience2014

Attenuated orexinergic signaling underlies depression-like responses induced by daytime light deficiency.

S P Deats, W Adidharma, J S Lonstein, L Yan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 62 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

S P DeatsDepartment of Psychology, Michigan State University, East Lansing, MI 48824, USA.
W AdidharmaDepartment of Psychology, Michigan State University, East Lansing, MI 48824, USA.
J S LonsteinDepartment of Psychology, Michigan State University, East Lansing, MI 48824, USA; Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA.
L YanDepartment of Psychology, Michigan State University, East Lansing, MI 48824, USA; Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA. Electronic address: yanl@msu.edu.
Michigan State University · US

Funding

Neural Basis for SAD: Development of a Diurnal Rodent ModelR03MH093760 · NIMH · MICHIGAN STATE UNIVERSITY · PI YAN, LILY · 2012 to 2013
$145k
NIMH NIH HHS R03 MH093760NIMH NIH HHS R03MH093760
6 · The paper itself

Abstract

Light has profound effects on mood, as exemplified by seasonal affective disorder (SAD) and the beneficial effects of bright light therapy. However, the underlying neural pathways through which light regulates mood are not well understood. Our previous work has developed the diurnal grass rat, Arvicanthis niloticus, as an animal model of SAD (Leach et al., 2013a,b). By utilizing a 12:12-h dim light:dark (DLD) paradigm that simulates the lower light intensity of winter, we showed that the animals housed in DLD exhibited increased depression-like behaviors in the forced swim test (FST) and sweet solution preference (SSP) compared to animals housed in bright light during the day (BLD). The objective of the present study was to test the hypothesis that light affects mood by acting on the brain orexinergic system in the diurnal grass rat model of SAD. First, orexin A immunoreactivity (OXA-ir) was examined in DLD and BLD grass rats. Results revealed a reduction in the number of OXA-ir neurons in the hypothalamus and attenuated OXA-ir fiber density in the dorsal raphe nucleus of animals in the DLD compared to those in the BLD group. Then, the animals in BLD were treated systemically with SB-334867, a selective orexin 1 receptor (OX1R) antagonist, which led to a depressive phenotype characterized by increased immobility in the FST and a decrease in SSP compared to vehicle-treated controls. Results suggest that attenuated orexinergic signaling is associated with increased depression-like behaviors in grass rats, and support the hypothesis that the orexinergic system mediates the effects of light on mood.

Indexed as

PhototherapySignal TransductionAnimalsAnxietyBehavior, AnimalBenzoxazolesCircadian RhythmDepressionDisease Models, AnimalIntracellular Signaling Peptides and ProteinsLightMaleMotor ActivityNaphthyridinesNeuropeptidesOrexins1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl ureaBenzoxazolesIntracellular Signaling Peptides and ProteinsNaphthyridinesNeuropeptidesOrexinsUreadiurnal grass ratsorexinSB-334867seasonal affective disorder

Identifiers

PMID24813431
PMCPMC4090246
OpenAlexW2074077441

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.