ArticleNature materials2014
Bacteria-instructed synthesis of polymers for self-selective microbial binding and labelling.
Article in Nature materials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 165 citations in OpenAlex.
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- Metabolism-Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Photo-excited extracellular electron transfer of electroactive microorganism triggers RAFT polymerization.Nature communications · 2025Article
- Highly sensitive Escherichia coli detection via cell surface in situ cytocompatible ATRP.Analytical and bioanalytical chemistry · 2025Article
- A novel strategy for Escherichia coli detection in raw beef in combination with click chemistry.NPJ science of food · 2025Article
- Cationic Polymer Brushes Functionalized with Carbon Dots and Boronic Acids for Bacterial Detection and Inactivation.ACS omega · 2025Article
- Applications of synthetic polymers directed toward living cells.Nature synthesis · 2024Article
- Tyrosine residues initiated photopolymerization in living organisms.Nature communications · 2023Article
- Review
- Shedding Light on Bacterial Physiology with Click Chemistry.Israel journal of chemistry · 2023Article
- Gram-negative bacterial sRNAs encapsulated in OMVs: an emerging class of therapeutic targets in diseases.Frontiers in cellular and infection microbiology · 2023Review
- Polymer Chemistry in Living Cells.Accounts of chemical research · 2022Article
- Polymer-induced biofilms for enhanced biocatalysis.Materials horizons · 2022Article
- Oxygen-Tolerant RAFT Polymerization Initiated by Living Bacteria.ACS macro letters · 2022Article
- Functionalization of Se-Te Nanorods with Au Nanoparticles for Enhanced Anti-Bacterial and Anti-Cancer Activities.Materials (Basel, Switzerland) · 2022Article
- Extracellular Electron Transfer Enables Cellular Control of Cu(I)-Catalyzed Alkyne-Azide Cycloaddition.ACS central science · 2022Article
- Engineered microorganism-based delivery systems for targeted cancer therapy: a narrative review.Biomaterials translational · 2022Review
- Engineering bacteria to control electron transport altering the synthesis of non-native polymer.RSC advances · 2021Article
- Heterocyclic Chemistry Applied to the Design ofMolecules (Basel, Switzerland) · 2021Review
- Synthetic biology as driver for the biologization of materials sciences.Materials today. Bio · 2021Review
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The detection and inactivation of pathogenic strains of bacteria continues to be an important therapeutic goal. Hence, there is a need for materials that can bind selectively to specific microorganisms for diagnostic or anti-infective applications, but that can be formed from simple and inexpensive building blocks. Here, we exploit bacterial redox systems to induce a copper-mediated radical polymerization of synthetic monomers at cell surfaces, generating polymers in situ that bind strongly to the microorganisms that produced them. This 'bacteria-instructed synthesis' can be carried out with a variety of microbial strains, and we show that the polymers produced are self-selective binding agents for the 'instructing' cell types. We further expand on the bacterial redox chemistries to 'click' fluorescent reporters onto polymers directly at the surfaces of a range of clinical isolate strains, allowing rapid, facile and simultaneous binding and visualization of pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.