ArticleMolecular pharmaceutics2014
PEG-polypeptide block copolymers as pH-responsive endosome-solubilizing drug nanocarriers.
Article in Molecular pharmaceutics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Stimuli-Responsive Carriers for Delivery of Anticancer Bioactive Agents.Materials (Basel, Switzerland) · 2026Review
- Dual Inhibition of KRAS G12D and PI3K/BRD4 signaling overcomes therapeutic resistance in pancreatic cancer.Acta biomaterialia · 2026Article
- Bioresponsive engineered nanoparticles for immunomodulation.BMC medicine · 2025Review
- Hydrogel Crosslinked with Nanoparticles for Prevention of Surgical Hemorrhage and Recurrence of Hepatocellular Carcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Advances in peptide-based drug delivery systems.Heliyon · 2024Review
- Polypeptide-Based Systems: From Synthesis to Application in Drug Delivery.Pharmaceutics · 2023Review
- CuAAC ensembled 1,2,3-triazole linked nanogels for targeted drug delivery: a review.RSC advances · 2023Review
- Hydrophilic Natural Polylysine as Drug Nanocarrier for Preparation of Helical Delivery System.Pharmaceutics · 2022Article
- Fluorescent labeling of biocompatible block copolymers: synthetic strategies and applications in bioimaging.Materials advances · 2021Review
- New side chain design for pH-responsive block copolymers for drug delivery.Colloids and surfaces. B, Biointerfaces · 2021Article
- Nanoplatforms for Targeted Stimuli-Responsive Drug Delivery: A Review of Platform Materials and Stimuli-Responsive Release and Targeting Mechanisms.Nanomaterials (Basel, Switzerland) · 2021Review
- Chemical Architecture of Block Copolymers Differentially Abrogate Cardiotoxicity and Maintain the Anticancer Efficacy of Doxorubicin.Molecular pharmaceutics · 2020Article
- Microenvironment-sensing, nanocarrier-mediated delivery of combination chemotherapy for pancreatic cancer.Journal of cell communication and signaling · 2019Article
- Dissecting the Cell Entry Pathway of Baculovirus by Single-Particle Tracking and Quantitative Electron Microscopic Analysis.Journal of virology · 2019Article
- PEG-b-poly (carbonate)-derived nanocarrier platform with pH-responsive properties for pancreatic cancer combination therapy.Colloids and surfaces. B, Biointerfaces · 2019Article
- Engineering Polymersomes for Diagnostics and Therapy.Advanced healthcare materials · 2018Review
- RNA-Peptide nanoplexes drug DNA damage pathways in high-grade serous ovarian tumors.Bioengineering & translational medicine · 2018Article
- Ligand-decorated click polypeptide derived nanoparticles for targeted drug delivery applications.Nanomedicine : nanotechnology, biology, and medicine · 2017Article
- Polyphosphoester nanoparticles as biodegradable platform for delivery of multiple drugs and siRNA.Drug design, development and therapy · 2017Article
- Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release.Chemical reviews · 2016Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Herein we report the potential of click chemistry-modified polypeptide-based block copolymers for the facile fabrication of pH-sensitive nanoscale drug delivery systems. PEG-polypeptide copolymers with pendant amine chains were synthesized by combining N-carboxyanhydride-based ring-opening polymerization with post-functionalization using azide-alkyne cycloaddition. The synthesized block copolymers contain a polypeptide block with amine-functional side groups and were found to self-assemble into stable polymersomes and disassemble in a pH-responsive manner under a range of biologically relevant conditions. The self-assembly of these block copolymers yields nanometer-scale vesicular structures that are able to encapsulate hydrophilic cytotoxic agents like doxorubicin at physiological pH but that fall apart spontaneously at endosomal pH levels after cellular uptake. When drug-encapsulated copolymer assemblies were delivered systemically, significant levels of tumor accumulation were achieved, with efficacy against the triple-negative breast cancer cell line, MDA-MB-468, and suppression of tumor growth in an in vivo mouse model.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.