ArticleNucleic acids research1989
Structure and biological activity of the transcriptional initiation sequences of the murine c-myb oncogene.
Article in Nucleic acids research, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Myb proteins: angels and demons in normal and transformed cells.Frontiers in bioscience (Landmark edition) · 2011Review
- GATA-1 and c-myb crosstalk during red blood cell differentiation through GATA-1 binding sites in the c-myb promoter.Oncogene · 2003Article
- Article
- Characterization of the mouse gene that encodes the delta/YY1/NF-E1/UCRBP transcription factor.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- In vivo treatment of human leukemia in a scid mouse model with c-myb antisense oligodeoxynucleotides.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Characterization of mouse-hamster somatic cell hybrids by PCR: a panel of mouse-specific primers for each chromosome.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Article
- Positive autoregulation of c-myb expression via Myb binding sites in the 5' flanking region of the human c-myb gene.Molecular and cellular biology · 1991Article
- An analysis of vertebrate mRNA sequences: intimations of translational control.The Journal of cell biology · 1991Review
- New nucleotide sequence data on the EMBL File Server.Nucleic acids research · 1990Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To study the control mechanism(s) that govern the transcription of c-myb, genomic clones corresponding to the 5' region of the murine c-myb gene have been isolated and characterized structurally and functionally. Primer extension and nuclease protection analysis have revealed the presence of multiple transcriptional initiation sites, that are utilized in several hemopoietic cell lines (WEHI3B(D+). FDC-P1 and RB22.2). Some of the sites are used in all cell lines but others are unique; all are located in a region of the c-myb gene that is G-C rich, contains a number of potential Sp1 binding sites and lacks classical promoter consensus sequences. Experiments in which well characterized promoters controlling expression of a reporter gene have been replaced by fragments of c-myb DNA (including the observed cap sites) were performed in an attempt to demonstrate promoter activity in various cell types. It was shown that a region of the c-myb gene (approximately 1.0 kbp upstream from the splice donor site of the first exon) contains a weak promoter that has a low level of transcriptional activity in hemopoietic as well as in fibroblastic cells. These results support the suggestion that c-myb expression is not regulated primarily at the level of initiation of transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.