Evidence map›Paper›PMID 24812638›Full record

ArticleJournal of cytology & molecular biology2013

Current Understanding and Future Directions for Vocal Fold Mechanobiology.

Nicole Y K Li, Hossein K Heris, Luc Mongeau

Open access · diamondAbstract read
In one paragraph

Article in Journal of cytology & molecular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Clinical Applications of Laryngeal Ultrasonography: A Review.Journal of voice : official journal of the Voice Foundation · 2025
    Review
  3. Article
  4. Observational
  5. Bioreactors for Vocal Fold Tissue Engineering.Tissue engineering. Part B, Reviews · 2022
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Indentation of poroviscoelastic vocal fold tissue using an atomic force microscope.Journal of the mechanical behavior of biomedical materials · 2013
    Article
  12. High-Performance Host-Device Scheduling and Data-Transfer Minimization Techniques for Visualization of 3D Agent-Based Wound Healing Applications.PDPTA '19 : proceedings of the 2019 International Conference on Parallel & Distributed Processing Techniquess & Applications. International Conference on Parallel and Distributed Processing Techniques and Applications (2019 : Las Vegas,...
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nicole Y K LiDepartment of Hearing and Speech Sciences, University of Maryland-College Park, College Park, Maryland, United States of America.
Hossein K HerisDepartment of Mechanical Engineering, McGill University, Montreal, Canada.
Luc MongeauDepartment of Mechanical Engineering, McGill University, Montreal, Canada.
University of Maryland, College Park · US

Funding

Fluid Structure Interactions Within the Human LarynxR01DC005788 · NIDCD · PURDUE UNIVERSITY WEST LAFAYETTE · PI MONGEAU, LUC · 2003 to 2018
$6.4M
Biosimulation of vocal fold surgical injuryR03DC012112 · NIDCD · UNIV OF MARYLAND, COLLEGE PARK · PI LI-JESSEN, NICOLE YEE-KEY · 2012 to 2014
$429k
NIDCD NIH HHS R01 DC005788NIDCD NIH HHS R03 DC012112
6 · The paper itself

Abstract

The vocal folds, which are located in the larynx, are the main organ of voice production for human communication. The vocal folds are under continuous biomechanical stress similar to other mechanically active organs, such as the heart, lungs, tendons and muscles. During speech and singing, the vocal folds oscillate at frequencies ranging from 20 Hz to 3 kHz with amplitudes of a few millimeters. The biomechanical stress associated with accumulated phonation is believed to alter vocal fold cell activity and tissue structure in many ways. Excessive phonatory stress can damage tissue structure and induce a cell-mediated inflammatory response, resulting in a pathological vocal fold lesion. On the other hand, phonatory stress is one major factor in the maturation of the vocal folds into a specialized tri-layer structure. One specific form of vocal fold oscillation, which involves low impact and large amplitude excursion, is prescribed therapeutically for patients with mild vocal fold injuries. Although biomechanical forces affect vocal fold physiology and pathology, there is little understanding of how mechanical forces regulate these processes at the cellular and molecular level. Research into vocal fold mechanobiology has burgeoned over the past several years. Vocal fold bioreactors are being developed in several laboratories to provide a biomimic environment that allows the systematic manipulation of physical and biological factors on the cells of interest

Indexed as

MechanobiologySystems biologyVocal folds

Identifiers

PMID24812638
PMCPMC4011392
OpenAlexW2052350799

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.