ArticleGastroenterology research and practice2014
The CIMP Phenotype in BRAF Mutant Serrated Polyps from a Prospective Colonoscopy Patient Cohort.
Article in Gastroenterology research and practice, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
30 citing papers in PubMed, 44 citations in OpenAlex.
- Attenuation of the CpG island methylator phenotype and lack of WNT signalling activation restrains Kras mutant intestinal neoplasia.British journal of cancer · 2026Article
- Colorectal Cancer: Pathogenesis and Targeted Therapy.MedComm · 2025Review
- Prevalence, risk factors, and BRAF mutation of colorectal sessile serrated lesions among Vietnamese patients.World journal of clinical oncology · 2024Article
- Transcription factor expression repertoire basis for epigenetic and transcriptional subtypes of colorectal cancers.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Development of a Large Colonoscopy-Based Longitudinal Cohort for Integrated Research of Colorectal Cancer: Partners Colonoscopy Cohort.Digestive diseases and sciences · 2022Article
- Genetic and epigenetic dependencies in colorectal cancer development.Gastroenterology report · 2022Review
- Four methylation-driven genes detected by linear discriminant analysis model from early-stage colorectal cancer and their methylation levels in cell-free DNA.Frontiers in oncology · 2022Article
- Article
- The Genomic Landscape of Serrated Lesion of the Colorectum: Similarities and Differences With Tubular and Tubulovillous Adenomas.Frontiers in oncology · 2021Article
- What could microRNA expression tell us more about colorectal serrated pathway carcinogenesis?World journal of gastroenterology · 2020Review
- Associations between molecular characteristics of colorectal serrated polyps and subsequent advanced colorectal neoplasia.Cancer causes & control : CCC · 2020Article
- Pathways of Colorectal Carcinogenesis.Gastroenterology · 2020Review
- DNA methylation instability by BRAF-mediated TET silencing and lifestyle-exposure divides colon cancer pathways.Clinical epigenetics · 2019Article
- An update on the morphology and molecular pathology of serrated colorectal polyps and associated carcinomas.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2019Review
- The association between colorectal sessile serrated adenomas/polyps and subsequent advanced colorectal neoplasia.Cancer causes & control : CCC · 2019Article
- Clinical, Pathological, and Molecular Characteristics of CpG Island Methylator Phenotype in Colorectal Cancer: A Systematic Review and Meta-analysis.Translational oncology · 2018Article
- Serrated neoplasia pathway as an alternative route of colorectal cancer carcinogenesis.Intestinal research · 2018Review
- Article
- How theGastroenterology research and practice · 2018Review
- Active BRAF-V600E is the key player in generation of a sessile serrated polyp-specific DNA methylation profile.PloS one · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal cancers arising via the serrated pathway are often associated with BRAF V600E mutation, CpG island methylator phenotype (CIMP), and microsatellite instability. Previous studies have shown a strong association between BRAF V600E mutation and serrated polyps. This study aims to evaluate CIMP status of all the serrated polyp subtypes and its association with functionally important genes such as MLH1, p16, and IGFBP7. CIMP status and methylation were evaluated using the real-time based MethyLight assay in 154 serrated polyps and 63 conventional adenomas. Results showed that CIMP-high serrated polyps were strongly associated with BRAF mutation and proximal colon. CIMP-high was uncommon in conventional adenomas (1.59%), occurred in 8.25% of hyperplastic polyps (HPs), and became common in sessile serrated adenomas (SSAs) (51.43%). MLH1 methylation was mainly observed in the proximal colon and was significantly associated with BRAF mutation and CIMP-high. The number of samples methylated for p16 and IGFBP7 was the highest in SSAs. The methylation panel we used to detect CIMP is highly specific for CIMP-high cancers. With this panel, we demonstrate that CIMP-high is much more common in SSAs than HPs. This suggests that CIMP-high correlates with increased risk of malignant transformation which was also observed in methylation of functionally important genes.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.