ArticleNutrition and metabolic insights2014
Intense exercise increases protein oxidation in spleen and liver of mice.
Article in Nutrition and metabolic insights, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 16 citations in OpenAlex.
- Trial
- Proteomic analysis emphasizes the adaptation of energy metabolism in horses during endurance races.BMC veterinary research · 2025Article
- Impact of ApoE Polymorphism and Physical Activity on Plasma Antioxidant Capability and Erythrocyte Membranes.Antioxidants (Basel, Switzerland) · 2019Article
- Association Between Hematological Parameters and Iron Metabolism Response After Marathon Race andFrontiers in physiology · 2019Article
- Effect of supplementation with chokeberry juice on the inflammatory status and markers of iron metabolism in rowers.Journal of the International Society of Sports Nutrition · 2014Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies have indicated that sports anemia is mainly associated with intravascular hemolysis induced by exercise. We hypothesized that such exercise-induced hemolysis leads to oxidative damage due to an increase in free iron caused by hematocyte destruction. Thirty-one male ICR mice were randomly divided into 3 groups: a rested control group, an intense-exercise group, and a group rested for 24 hours after intense exercise. The serum haptoglobin level of the intense-exercise group decreased compared with that of the rested control group, suggesting hemolysis. Tissue iron and protein carbonyl levels in the liver were increased after exercise, and the protein carbonyl level in the spleen on the day after exercise was significantly increased compared with that of the resting state. These results suggest that the spleen and liver, where extravascular hemolysis occurs, were subjected to oxidative modification by the free iron, which was released from large numbers of hemocytes that were destroyed due to the intense exercise.
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