ReviewNeuropsychiatric disease and treatment2014
Solitary skull metastasis as the first symptom of hepatocellular carcinoma: case report and literature review.
Review in Neuropsychiatric disease and treatment, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Beyond the Usual Suspects: Atypical Dural-Based Tumors With Rare Histology and Intracranial Extension.Brain tumor research and treatment · 2026Article
- Lytic bone lesion of the skull as a rare manifestation of hepatocellular carcinoma: a case report.Patient safety in surgery · 2025Article
- Isolated calvarial lesion as the initial presentation of metastatic hepatocellular carcinoma: A case report and review of the literature.Surgical neurology international · 2025Article
- Clival metastasis of hepatocellular carcinoma: a case report of a rare skull-base malignancy.Frontiers in oncology · 2025Article
- Beyond the liver: a case of solitary skull lesion with hepatocellular features without a primary malignancy.Ecancermedicalscience · 2025Article
- Metastatic hepatocellular carcinoma presenting as a lytic calvarial mass.Clinical case reports · 2024Article
- Skull Metastasis With Orbital Invasion as a Primary Manifestation of Hepatocellular Carcinoma.Cureus · 2024Article
- Solitary metastasis to the skull as the first sign of hepatocellular carcinoma in a patient in long-term remission.Surgical neurology international · 2023Article
- Response of Scalp and Skull Metastasis to Anti-PD-1 Antibody Combined with Regorafenib Treatment in a Sorafenib-Resistant Hepatocellular Carcinoma Patient and a Literature Review.OncoTargets and therapy · 2022Article
- Skull Base Metastasis from Hepatocellular Carcinoma: Clinical Presentation and Efficacy of Radiotherapy.Journal of hepatocellular carcinoma · 2022Article
- A Rare Case of Metastatic Hepatocellular Carcinoma Masquerading as a Forehead Hematoma.Case reports in gastrointestinal medicine · 2020Article
- Superior Sagittal Sinus Tumor Eroding through the Skull: An Unfamiliar Presentation of Hepatocellular Carcinoma and Literature Review.Case reports in surgery · 2019Article
- Lung cancer metastasis presenting as a solitary skull mass.Journal of surgical case reports · 2016Article
- Retrobulbar metastasis and intracranial invasion from postoperative hepatocellular carcinoma: A case report and review of the literature.Oncology letters · 2015Article
- Painless lump over the forehead which turned painful: an unusual presentation of hepatocellular carcinoma.BJR case reports · 2015Article
- Skull metastasis from follicular thyroid carcinoma: report of three cases and review of literature.International journal of clinical and experimental pathology · 2015Review
- Palliative external-beam radiotherapy for bone metastases from hepatocellular carcinoma.World journal of hepatology · 2014Review
- Successful Treatment of Anal Canal Cancer Metastasis to the Cranial Bones: A Case Report and Literature Review.In vivo (Athens, Greece)Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skull metastasis from hepatocellular carcinoma (HCC) is reported rarely. In addition, solitary skull metastasis as the first symptom of HCC is reported even less. Here, we reported a case of solitary skull metastasis as the first symptom of HCC and reviewed the literature on skull metastasis. A 49-year-old male patient was admitted to Jinjiang Hospital of Quanzhou Medical College with a painless parietal-occipital scalp mass, and he denied any history of hepatic disease. A cranial computed tomography demonstrated a hypervascular enhancement with osteolytic change in the right parietal-occipital region, cranial magnetic resonance imaging indicated a highly enhanced and osteolytic skull tumor, and abdominal computed tomography showed a huge tumor in the liver. The other examinations showed no other metastases. Laboratory data showed no liver dysfunction while hepatitis B surface antigen was positive, and alpha fetal protein level was high. A craniectomy was performed and the mass was totally removed. The histological diagnosis was skull metastasis from HCC. The patient was subsequently treated by transcatheter arterial chemoembolization. In a review of published literature, the incidence of skull metastasis from HCC in the period between 1990 and 2011 has significantly increased. The misdiagnosis rate of skull metastases as the first symptom from HCC was high. Therefore, it is necessary to give each patient with a scalp mass that has invaded the skull a liver ultrasound or computed tomography scan. On the other hand, we found that metastases that occurred in the calvaria site were more frequent than those that occurred in the skull base and facial skeleton. This may be worthy of further investigation in the future.
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