ArticleInternational journal of nanomedicine2014
Evaluation of renal quantitative T2* changes on MRI following administration of ferumoxytol as a T2* contrast agent.
Article in International journal of nanomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 6 citations in OpenAlex.
- Effect of clinically relevant iron oxide nanoparticles on macrophage polarization, tumor growth and tumor microenvironment modulation.Journal of controlled release : official journal of the Controlled Release Society · 2026Article
- Comparison of methods for in vivo and ex vivo quantification of iron in murine brain tumors.PloS one · 2026Article
- Ferumoxytol magnetic resonance angiography: a dose-finding study in patients with chronic kidney disease.European radiology · 2019Article
- Ferumoxytol-enhanced magnetic resonance angiography for the assessment of potential kidney transplant recipients.European radiology · 2018Article
- Prediction of Anti-cancer Nanotherapy Efficacy by Imaging.Nanotheranostics · 2017Review
- Radiologic imaging of the renal parenchyma structure and function.Nature reviews. Nephrology · 2016Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo evaluate the time-dependent changes in regional quantitative T2* maps of the kidney following intravenous administration of ferumoxytol. MATERIALS AND
methodsTwenty-four individuals with normal kidney function underwent T2*-weighted MRI of the kidney before, immediately after, and 48 hours after intravenous administration of ferumoxytol at a dose of 4 mg/kg (group A, n=12) or 6 mg/kg (group B, n=12). T2* values were statistically analyzed using two-tailed paired t-tests.
resultsIn group A, the percentage changes from baseline to immediate post and baseline to 48 hours were 85.3% and 64.2% for the cortex and 90.8% and 64.6% for the medulla, respectively. In group B, the percentage changes from baseline to immediate post and baseline to 48 hours were 85.2% and 73.4% for the cortex and 94.5% and 74% for the medulla, respectively. This difference was significant for both groups (P<0.0001).
conclusionThere is significant and differential uptake of ferumoxytol in the cortex and medulla of physiologically normal kidneys. This differential uptake may offer the ability to interrogate renal cortex and medulla with possible clinical applications in medical renal disease and transplant organ assessment. We propose an organ of interest based dose titration of ferumoxytol to better differentiate circulating from intracellular ferumoxytol particles.
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