ArticleJournal of Ayurveda and integrative medicine2014
Immunophenotyping of normal individuals classified on the basis of human dosha prakriti.
Article in Journal of Ayurveda and integrative medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- A scoping review of clinicalFrontiers in medicine · 2026Pooled it
- Reliability of Ayurvedic Diagnosis for Knee Osteoarthritis Patients: A Nested Diagnostic Study Within a Randomized Controlled Trial.Journal of alternative and complementary medicine (New York, N.Y.) · 2019Trial
- Predicting susceptibility to inflammaging using a genetic inflammatory index through Prakriti-based phenotypic stratification.Frontiers in immunology · 2026Article
- Prakriti (constitutional typology) in Ayurveda: a critical review of Prakriti assessment tools and their scientific validity.Frontiers in medicine · 2025Review
- Ayurgenomics-based frameworks in precision and integrative medicine: Translational opportunities.Cambridge prisms. Precision medicine · 2023Review
- An Ayurgenomics Approach: Prakriti-Based Drug Discovery and Development for Personalized Care.Frontiers in pharmacology · 2022Review
- Ayurgenomics and Modern Medicine.Medicina (Kaunas, Lithuania) · 2020Review
- Comparative gut microbiome analysis of the3 Biotech · 2020Article
- Functional signature analysis of extreme Prakriti endophenotypes in gut microbiome of western Indian rural population.Bioinformation · 2019Article
- Genomic insights into ayurvedic and western approaches to personalized medicine.Journal of genetics · 2016Review
- Genome-wide analysis correlates Ayurveda Prakriti.Scientific reports · 2015Article
- DNA methylation analysis of phenotype specific stratified Indian population.Journal of translational medicine · 2015Article
- Determinants of prakriti, the human constitution types of Indian traditional medicine and its correlation with contemporary science.Journal of Ayurveda and integrative medicine · 2014Article
- Significance of arterial stiffness in Tridosha analysis: A pilot study.Journal of Ayurveda and integrative medicineArticle
- Exploring AyuGenomics approach for understanding COVID-19 predisposition and progression.Journal of Ayurveda and integrative medicineReview
- Integrating ayurvedic medicine into cancer research programs part 1: Ayurveda background and applications.Journal of Ayurveda and integrative medicineReview
- An Ayurvedic personalized prophylactic protocol in COVID-19.Journal of Ayurveda and integrative medicineReview
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman variations related to immune response and disease susceptibility is well-documented in Ayurveda. Prakriti (body constitution) is the basic constitution of an individual established at the time of birth and distinguishes variations, into three broad phenotype categories such as vata, pitta and kapha. Variation in immune response is often attributed to and measured from the difference in cluster differentiation (CD) markers expressed in lymphocytes. Currently, there are no reports available on the expression of CD markers related to prakriti.
objectiveThis is a pilot study performed to evaluate a panel of lymphocyte subset CD markers in dominant prakriti individuals. MATERIALS AND
methodsImmunophenotyping was carried out using whole blood from a total of healthy 222 subjects, who are grouped into kapha (n = 95), pitta (n = 57) and vata (n = 70) prakritis. CD markers such as CD3, CD4, CD8, CD14, CD25, CD56, CD69, CD71 and HLA-DR were analyzed using flow cytometry method. Differences between groups were analyzed using one-way ANOVA or Kruskal-Wallis analysis of variance (ANOVA) and multiple comparisons between groups were performed by Bonferroni or Mann-Whitney U test with corrections for type I error respectively. Significance was evaluated by ANOVA and Pearson's correlation.
resultsWe observed a significant difference (P < 0.05) in the expression of CD markers such as CD14 (monocytes), CD25 (activated B cells) and CD56 (Natural killer cells) between different prakriti groups. CD25 and CD56 expression was significantly higher in kapha prakriti samples than other prakriti groups. Similarly, slightly higher levels of CD14 were observed in pitta prakriti samples.
conclusionSignificant difference in the expression of CD14, CD25 and CD56 markers between three different prakriti is demonstrated. The increased level of CD25 and CD56 in kapha prakriti may indicate ability to elicit better immune response, which is in conformity with textual references in Ayurveda.
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