Evidence map›Paper›PMID 2481229›Full record

ArticleMolecular and cellular biology1989

cDNA structures and regulation of two interferon-induced human Mx proteins.

M Aebi, J Fäh, N Hurt, C E Samuel, D Thomis, L Bazzigher, J Pavlovic, O Haller, P Staeheli

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PubMed Full text at PMC Publisher
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Article in Molecular and cellular biology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers.

0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

130 citing papers in PubMed.

  1. Article
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  8. Review
  9. HIV-1 resists MxB inhibition of viral Rev protein.Emerging microbes & infections · 2020
    Article
  10. Article
  11. IFNs Drive Development of Novel IL-15-Responsive Macrophages.Journal of immunology (Baltimore, Md. : 1950) · 2020
    Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
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  20. Article

70 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

M AebiInstitute for Molecular Biology I, University of Zurich, Switzerland.
J Fäh
N Hurt
C E Samuel
D Thomis
L Bazzigher
J Pavlovic
O Haller
P Staeheli

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human cells treated with interferon synthesize two proteins that exhibit high homology to murine Mx1 protein, which has previously been identified as the mediator of interferon-induced cellular resistance of mouse cells against influenza viruses. Using murine Mx1 cDNA as a hybridization probe, we have isolated cDNA clones originating from two distinct human Mx genes, designated MxA and MxB. In human fibroblasts, expression of MxA and MxB is strongly induced by alpha interferon (IFN-alpha), IFN-beta, Newcastle disease virus, and, to a much lesser extent, IFN-gamma, MxA and MxB proteins have molecular masses of 76 and 73 kilodaltons, respectively, and their sequences are 63% identical. A comparison of human and mouse Mx proteins revealed that human MxA and mouse Mx2 are the most closely related proteins, showing 77% sequence identity. Near their amino termini, human and mouse Mx proteins contain a block of 53 identical amino acids and additional regions of very high sequence similarity. These conserved sequences are also present in a double-stranded RNA-inducible fish gene, which suggests that they may constitute a functionally important domain of Mx proteins. In contrast to mouse Mx1 protein, which accumulates in the nuclei of IFN-treated mouse cells, the two human Mx proteins both accumulate in the cytoplasm of IFN-treated cells.

Indexed as

Gene Expression RegulationGTP-Binding ProteinsAmino Acid SequenceAnimalsBase SequenceBlotting, NorthernCell LineCytoplasmDNAFishesHumansInterferon-gammaInterferonsInterferon Type IMiceMolecular Sequence DataDNAGTP-Binding ProteinsInterferon-gammaInterferonsInterferon Type IMX1 protein, humanMx1 protein, mouseMX2 protein, humanMx2 protein, mouseMyxovirus Resistance ProteinsProteinsRecombinant Proteins

Identifiers

PMID2481229
PMCPMC363658

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.