ArticleJournal of the American Society of Nephrology : JASN2014
Childhood kidney outcomes in relation to fetal blood flow and kidney size.
Article in Journal of the American Society of Nephrology : JASN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Correlation between Prenatal Fetal Hemodynamic Parameters and Growth Indices in Pregnant Women with Preeclampsia and Neonatal Ultrasound Indicators of Organ Development.Pakistan journal of medical sciences · 2026Article
- Early life factors and variation in adult kidney function in the Swedish LifeGene cohort.Scientific reports · 2025Article
- Maternal Hypertension Disorders and Neonatal Acute Kidney Injury: Results from the AWAKEN Study.American journal of perinatology · 2024Article
- Role of foetal kidney size on kidney function in childhood: the born in bradford cohort renal study.BMC nephrology · 2023Article
- The effects ofJournal of developmental origins of health and disease · 2021Article
- The old becomes new: advances in imaging techniques to assess nephron mass in children.Pediatric nephrology (Berlin, Germany) · 2021Review
- Associations of maternal metabolic profile with placental and fetal cerebral and cardiac hemodynamics.European journal of obstetrics, gynecology, and reproductive biology · 2021Article
- Normal foetal kidney volume in offspring of women treated for gestational diabetes.Endocrinology, diabetes & metabolism · 2019Article
- Influence of fetal blood flow redistribution on fetal and childhood growth and fat distribution: the Generation R Study.BJOG : an international journal of obstetrics and gynaecology · 2016Article
- The Generation R Study: design and cohort update 2017.European journal of epidemiology · 2016Article
- Are low birth weight neonates at risk for suboptimal renal growth and function during infancy?BMC nephrology · 2016Article
- The Generation R Study: Biobank update 2015.European journal of epidemiology · 2014Article
- The life cycle of the kidney: implications for CKD.Journal of the American Society of Nephrology : JASN · 2014Article
- Development: Fetal growth and renal outcomes.Nature reviews. Nephrology · 2014Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Impaired fetal abdominal blood flow may lead to smaller kidneys and subsequent impaired kidney function in later life. In a prospective cohort study among 923 pregnant women and their children, we measured fetal growth, kidney volumes, and umbilical and cerebral artery blood flow (median gestational age of 30.3 weeks; 95% range, 28.5-32.7 weeks). We used a higher umbilical/cerebral artery pulsatility index ratio as an indicator of preferential fetal blood flow to the upper body parts at the expense of the intra-abdominal organs. At a median age of 5.9 years (95% range, 5.7-6.6 years), we measured childhood kidney volumes, creatinine and cystatin C blood levels, microalbuminuria, BP, and eGFR. A preferential fetal blood flow to the upper body parts at the expense of the intra-abdominal organs associated only with a smaller combined kidney volume in childhood. Fetal combined kidney volume positively associated with childhood combined kidney volume and eGFR, and inversely associated with childhood creatinine and cystatin C levels (all P values <0.05), but did not associate with childhood microalbuminuria and BP. Children within the highest tertile of fetal umbilical/cerebral ratio and the lowest tertile of fetal combined kidney volume had the lowest eGFR (difference, -6.36 ml/min per 1.73 m(2); 95% confidence interval, -11.78 to -0.94 compared with children within the middle tertiles). These data suggest that impaired fetal blood to the abdominal organs and smaller fetal kidney size are associated with subclinical changes in kidney outcomes in school-aged children.
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