ArticleJournal of the American Society of Nephrology : JASN2014
Fetal and infant growth patterns and kidney function at school age.
Article in Journal of the American Society of Nephrology : JASN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Effect of Protein Intake Early in Life on Kidney Volume and Blood Pressure at 11 Years of Age.Nutrients · 2023Trial
- Maternal and fetal determinants on kidney size in early childhood: insights from a New York City cohort.BMC nephrology · 2026Article
- Role of foetal kidney size on kidney function in childhood: the born in bradford cohort renal study.BMC nephrology · 2023Article
- Preterm Birth, Kidney Function and Cardiovascular Disease in Children and Adolescents.Children (Basel, Switzerland) · 2022Review
- Mismatch between poor fetal growth and rapid postnatal weight gain in the first 2 years of life is associated with higher blood pressure and insulin resistance without increased adiposity in childhood: the GUSTO cohort study.International journal of epidemiology · 2020Article
- Features of and preventive measures against hypertension in the young.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Review
- Temporal trends in renal function and birthweight in Japanese adolescent males (1998-2015).Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2018Article
- Fetal first trimester growth is not associated with kidney outcomes in childhood.Pediatric nephrology (Berlin, Germany) · 2017Article
- Influence of common genetic variants on childhood kidney outcomes.Pediatric research · 2016Article
- Protein intake in infancy and kidney size and function at the age of 6 years: The Generation R Study.Pediatric nephrology (Berlin, Germany) · 2015Article
- Birth weight, malnutrition and kidney-associated outcomes--a global concern.Nature reviews. Nephrology · 2015Review
- The Generation R Study: Biobank update 2015.European journal of epidemiology · 2014Article
- The life cycle of the kidney: implications for CKD.Journal of the American Society of Nephrology : JASN · 2014Article
- Development: Fetal growth and renal outcomes.Nature reviews. Nephrology · 2014Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low birth weight is associated with ESRD. To identify specific growth patterns in early life that may be related to kidney function in later life, we examined the associations of longitudinally measured fetal and infant growth with kidney function in school-aged children. This study was embedded in a population-based prospective cohort study among 6482 children followed from fetal life onward. Fetal and childhood growth was measured during second and third trimesters of pregnancy, at birth, and at 6, 12, 24, 36, and 48 months postnatally. At the age of 6 years, we measured kidney volume by ultrasound. GFR was estimated using blood creatinine levels. Higher gestational age-adjusted birth weight was associated with higher combined kidney volume and higher eGFR (per 1 SD score increase in birth weight; 1.27 cm(3) [95% confidence interval, 0.61 to 1.93] and 0.78 ml/min per 1.73 m2 [95% CI, 0.16 to 1.39], respectively). Fetal weight, birth weight, and weight at 6 months were positively associated with childhood kidney volume, whereas higher second trimester fetal weight was positively associated with higher GFR (all P values<0.05). Fetal and childhood lengths were not consistently associated with kidney function. In this cohort, lower fetal and early infant weight growth is associated with smaller kidney volume in childhood, whereas only lower fetal weight growth is associated with lower kidney function in childhood, independent of childhood growth. Whether these associations lead to an increased risk of kidney disease needs to be studied further.
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