Evidence map›Paper›PMID 24812163›Full record

ReviewJournal of the American Society of Nephrology : JASN2014

Approaches to uremia.

Timothy W Meyer, Thomas H Hostetter

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of the American Society of Nephrology : JASN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 55 citations in OpenAlex.

  1. Trial
  2. Serum Asymmetric and Symmetric Dimethylarginine and Morbidity and Mortality in Hemodialysis Patients.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2017
    Trial
  3. Trimethylamine N-Oxide and Cardiovascular Events in Hemodialysis Patients.Journal of the American Society of Nephrology : JASN · 2017
    Trial
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Association of trimethylamineRenal failure · 2020
    Article
  15. Review
  16. Article
  17. Article
  18. The renal replacement therapy landscape in 2030: reducing the global cardiovascular burden in dialysis patients.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020
    Review
  19. Cognitive Impairment in CKD: Pathophysiology, Management, and Prevention.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Timothy W MeyerDepartment of Medicine, Veterans Affairs Palo Alto Healthcare System, Palo Alto, California; Department of Medicine, Stanford University, Palo Alto, California; and twmeyer@stanford.edu.
Thomas H HostetterDepartment of Medicine, Case Western Reserve University, Cleveland, Ohio.
Case Western Reserve University · USVA Palo Alto Health Care System · US

Funding

Retained Organic Solutes and Clinical Outcomes in HemodialysisR01DK080123 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI POWE, NEIL R. · 2008 to 2012
$3.2M
The Production of Uremic Solutes by Colon MicrobesR21DK084439 · NIDDK · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI MEYER, TIMOTHY W · 2009 to 2010
$406k
NIDDK NIH HHS R01 DK080123NIDDK NIH HHS R01-DK80123NIDDK NIH HHS R21 DK084439NIDDK NIH HHS R21-DK84439
6 · The paper itself

Abstract

The development of dialysis was a dramatic step forward in medicine, allowing people who would soon have died because of lack of kidney function to remain alive for years. We have since found, however, that the "artificial kidney" does not live up fully to its name. Dialysis keeps patients alive but not well. Part of the residual illness that dialysis patients experience is caused by retained waste solutes that dialysis does not remove as well as native kidney function does. New means are available to identify these toxic solutes, about which we currently know remarkably little, and knowledge of these solutes would help us to improve therapy. This review summarizes our current knowledge of toxic solutes and highlights methods being explored to identify additional toxic solutes and to enhance the clearance of these solutes to improve patient outcomes.

Indexed as

AnimalsHumansKidney Failure, ChronicKidney TubulesRenal DialysisUreaUremiaUreachronic dialysisureauremia

Identifiers

PMID24812163
PMCPMC4178448
OpenAlexW2137802963

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.