ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2014
Low pH enhances connexin32 degradation in the pancreatic acinar cell.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- pH-Dependence of Glucose-Dependent Activity of Beta Cell Networks in Acute Mouse Pancreatic Tissue Slice.Frontiers in endocrinology · 2022Article
- Adhesion molecules and pancreatitis.Journal of gastroenterology · 2019Review
- Bidirectional Relationship Between Reduced Blood pH and Acute Pancreatitis: A Translational Study of Their Noxious Combination.Frontiers in physiology · 2018Article
- Nutrient Starvation Decreases Cx43 Levels and Limits Intercellular Communication in Primary Bovine Corneal Endothelial Cells.The Journal of membrane biology · 2016Article
- Connexins: substrates and regulators of autophagy.BMC cell biology · 2016Review
- The conspiracy of autophagy, stress and inflammation in acute pancreatitis.Current opinion in gastroenterology · 2014Review
- A prediction model for acute respiratory distress syndrome among patients with severe acute pancreatitis: a retrospective analysis.Therapeutic advances in respiratory diseaseArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Decreased extracellular pH is observed in a number of clinical conditions and can sensitize to the development and worsen the severity of acute pancreatitis. Because intercellular communication through gap junctions is pH-sensitive and modulates pancreatitis responses, we evaluated the effects of low pH on gap junctions in the rat pancreatic acinar cell. Decreasing extracellular pH from 7.4 to 7.0 significantly inhibited gap junctional intracellular communication. Acidic pH also significantly reduced levels of connexin32, the predominant gap junction protein in acinar cells, and altered its localization. Increased degradation through the proteasomal, lysosomal, and autophagic pathways mediated the decrease in connexin32 under low-pH conditions. These findings provide the first evidence that low extracellular pH can regulate gap junctional intercellular communication by enhancing connexin degradation.
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Registered trials
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