ArticleToxicological sciences : an official journal of the Society of Toxicology2014
Acrolein decreases endothelial cell migration and insulin sensitivity through induction of let-7a.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 48 citations in OpenAlex.
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- Acrolein exposure associated with kidney damage: a cross‑sectional study.Scientific reports · 2025Article
- Volatile organic compounds exposure in relation to glucose homeostasis and type 2 diabetes in older adults from the NHANES.Scientific reports · 2024Article
- Associations between specific volatile organic chemical exposures and cardiovascular disease risks: insights from NHANES.Frontiers in public health · 2024Article
- Exposure to Volatile Organic Compounds Is Associated with Hypertension in Black Adults: The Jackson Heart Study.Environmental research · 2023Article
- Acrolein inhalation acutely affects the regulation of mitochondrial metabolism in rat lung.Toxicology · 2022Article
- Effect of a Low Dose of Carvedilol on Cyclophosphamide-Induced Urinary Toxicity in Rats-A Comparison with Mesna.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Fine particulate matter air pollution and aortic perivascular adipose tissue: Oxidative stress, leptin, and vascular dysfunction.Physiological reports · 2021Article
- Article
- Low-Dose Acrolein, an Endogenous and Exogenous Toxic Molecule, Inhibits Glucose Transport via an Inhibition of Akt-Regulated GLUT4 Signaling in Skeletal Muscle Cells.International journal of molecular sciences · 2021Article
- Exposure to volatile organic compounds - acrolein, 1,3-butadiene, and crotonaldehyde - is associated with vascular dysfunction.Environmental research · 2021Article
- Epimutational effects of electronic cigarettes.Environmental science and pollution research international · 2021Review
- Serum-borne factors alter cerebrovascular endothelial microRNA expression following particulate matter exposure near an abandoned uranium mine on the Navajo Nation.Particle and fibre toxicology · 2020Article
- Role of Heparin-Binding Epidermal Growth Factor-Like Growth Factor in Oxidative Stress-Associated Metabolic Diseases.Metabolic syndrome and related disorders · 2020Review
- A Regulator of Metabolic Reprogramming: MicroRNA Let-7.Translational oncology · 2019Article
- Flavorings in Tobacco Products Induce Endothelial Cell Dysfunction.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- Inhalation of Fine Particulate Matter Impairs Endothelial Progenitor Cell Function Via Pulmonary Oxidative Stress.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- Biomarkers of Chronic Acrolein Inhalation Exposure in Mice: Implications for Tobacco Product-Induced Toxicity.Toxicological sciences : an official journal of the Society of Toxicology · 2017Article
- Transcriptome Profiling in Systems Vascular Medicine.Frontiers in pharmacology · 2017Article
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7 authors at 2 institutions in 2 countries.
Funding
Abstract
Acrolein is a major reactive component of vehicle exhaust, and cigarette and wood smoke. It is also present in several food substances and is generated endogenously during inflammation and lipid peroxidation. Although previous studies have shown that dietary or inhalation exposure to acrolein results in endothelial activation, platelet activation, and accelerated atherogenesis, the basis for these effects is unknown. Moreover, the effects of acrolein on microRNA (miRNA) have not been studied. Using AGILENT miRNA microarray high-throughput technology, we found that treatment of cultured human umbilical vein endothelial cells with acrolein led to a significant (>1.5-fold) upregulation of 12, and downregulation of 15, miRNAs. Among the miRNAs upregulated were members of the let-7 family and this upregulation was associated with decreased expression of their protein targets, β3 integrin, Cdc34, and K-Ras. Exposure to acrolein attenuated β3 integrin-dependent migration and reduced Akt phosphorylation in response to insulin. These effects of acrolein on endothelial cell migration and insulin signaling were reversed by expression of a let-7a inhibitor. Also, inhalation exposure of mice to acrolein (1 ppm x 6 h/day x 4 days) upregulated let-7a and led to a decrease in insulin-stimulated Akt phosphorylation in the aorta. These results suggest that acrolein exposure has broad effects on endothelial miRNA repertoire and that attenuation of endothelial cell migration and insulin signaling by acrolein is mediated in part by the upregulation of let-7a. This mechanism may be a significant feature of vascular injury caused by inflammation, oxidized lipids, and exposure to environmental pollutants.
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