Observational studyJournal of the American Heart Association2014
Clinical features and prognosis of patients with coronary spasm-induced non-ST-segment elevation acute coronary syndrome.
Observational study in Journal of the American Heart Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
- Development and Validation of Artificial Intelligence Prediction of Epicardial Coronary Artery Spasm in Patients Without Obstructive Coronary Artery Disease.Diagnostics (Basel, Switzerland) · 2026Article
- Sex-specific and ethnicity-specific differences in MINOCA.Nature reviews. Cardiology · 2024Review
- Coronary Spasm Testing with Acetylcholine: A Powerful Tool for a Personalized Therapy of Coronary Vasomotor Disorders.Life (Basel, Switzerland) · 2024Review
- Characterization of global research trends and prospects on sudden coronary death: A literature visualization analysis.Heliyon · 2023Article
- Invasive Evaluation for Coronary Vasospasm.US cardiology · 2023Review
- Inferior STEMI Electrocardiogram in a Young Postpartum Female with Sickle Cell Trait with Chest Pain - A Case Report.Journal of education & teaching in emergency medicine · 2022Article
- Role of Intracoronary Imaging in Acute Coronary Syndromes.US cardiology · 2022Review
- Out-of-hospital cardiac arrest due to acute myocardial infarction possibly caused by coronary vasospasm.Journal of cardiology cases · 2022Article
- Review Article--Clinical Overview of Myocardial Infarction Without Obstructive Coronary Artey Disease (MINOCA).Journal of the Saudi Heart Association · 2021Article
- Role of acetylcholine spasm provocation test as a pathophysiological assessment in nonobstructive coronary artery disease.Cardiovascular intervention and therapeutics · 2021Review
- Non-atherosclerotic causes of acute coronary syndromes.Nature reviews. Cardiology · 2020Review
- Microvascular spasm in non-ST-segment elevation myocardial infarction without culprit lesion (MINOCA).Clinical research in cardiology : official journal of the German Cardiac Society · 2020Article
- Occurrence and mortality of vasospastic angina pectoris hospitalised patients in Finland: a population-based registry cohort study.BMJ open · 2019Article
- Typical ST-segment elevation myocardial infarction with normal coronary arteries: a case report.The Journal of international medical research · 2019Article
- Vasoconstrictor component of atherothrombotic culprit lesions in ST-segment elevation myocardial infarction.Journal of the Saudi Heart Association · 2019Article
- Acute Coronary Syndrome With Normal Coronary Arteries: a Case of Spontaneous Spasm Lysis.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2018Article
- Out-of-hospital cardiac arrest related to coronary arterial spasm in three elderly patients with no obstructive coronary artery disease.Journal of cardiology cases · 2017Article
- Unique Presentations and Etiologies of Myocardial Infarction in Women.Current treatment options in cardiovascular medicine · 2017Review
- Late gadolinium enhancement on cardiac magnetic resonance predicts coronary vasomotor abnormality and myocardial lactate production in patients with chronic heart failure.Heart and vessels · 2016Article
- Clinical Outcomes of Vasospastic Angina Patients Presenting With Acute Coronary Syndrome.Journal of the American Heart Association · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prevalence, clinical features, and long-term outcome of patients with non-ST-segment elevation acute coronary syndrome (NSTE ACS) associated with coronary spasm are not fully investigated. METHODS AND
resultsThis observational multicenter study enrolled 1601 consecutive patients with suspected NSTE-ACS who underwent cardiac catheterization between January 2001 and December 2010. A culprit lesion was found in 1152 (72%) patients. In patients without a culprit lesion, the acetylcholine provocation test was performed in 221 patients and was positive in 175 patients. In the other patients, coronary spasm was verified in 145 patients during spontaneous attack. Spasm-induced NSTE-ACS was diagnosed in 320 (20%) patients. Multivariable analysis identified age <70 years (odds ratio [OR] 2.19, 95% CI 1.58 to 3.04), estimated glomerular filtration rate >60 mL/min per 1.73 m(2) (OR 1.72, 95% CI 1.16 to 2.56), and lack of hypertension (OR 2.55, 95% CI 1.90 to 3.41), dyslipidemia (OR 2.76, 95% CI 2.05 to 3.73), diabetes mellitus (OR 2.49, 95% CI 1.78 to 3.48), previous myocardial infarction (OR 5.37, 95% CI 2.89 to 10.0), and elevated cardiac biomarkers (OR 2.84, 95% CI 2.11 to 3.83) as significant correlates of spasm-induced NSTE-ACS (P<0.01 for all variables). Transient ST-segment elevation during spontaneous attack (variant angina) was observed in 119 patients with spasm-induced NSTE-ACS. Variant angina was more common in nondyslipidemic men among patients with spasm-induced NSTE-ACS.
conclusionsThe study showed frequent involvement of coronary spasm in the pathogenesis of NSTE-ACS. Variant angina was observed in one third of patients with spasm-induced NSTE-ACS. Coronary spasm should be considered even in patients with less coronary risk factors and nonobstructive coronary arteries.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.