ArticlePloS one2014
Roles of the sodium-translocating NADH:quinone oxidoreductase (Na+-NQR) on vibrio cholerae metabolism, motility and osmotic stress resistance.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
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- Microbial diversity and metabolic potential in long-term Cr(VI) polluted soil during in situ biostimulation: a pilot effective assay.Environmental science and pollution research international · 2025Article
- Single-strain behavior predicts responses to environmental pH and osmolality in the gut microbiota.mBio · 2023Article
- Vibrio natriegens genome-scale modeling reveals insights into halophilic adaptations and resource allocation.Molecular systems biology · 2023Article
- Insights into theAntibiotics (Basel, Switzerland) · 2022Article
- Insights into the chemistry of the amphibactin-metal (MScientific reports · 2020Article
- RNA-mediated control of cell shape modulates antibiotic resistance in Vibrio cholerae.Nature communications · 2020Article
- Genetic Dissection of the Fermentative and Respiratory Contributions Supporting Vibrio cholerae Hypoxic Growth.Journal of bacteriology · 2020Article
- NamBio · 2020Article
- Targeting Type IV pili as an antivirulence strategy against invasive meningococcal disease.Nature microbiology · 2019Article
- Amino acids as wetting agents: surface translocation by Porphyromonas gingivalis.The ISME journal · 2019Article
- Mr.Vc: a database of microarray and RNA-seq of Vibrio cholerae.Database : the journal of biological databases and curation · 2019Article
- Genus-Wide Comparative Genomics Analysis ofInternational journal of genomics · 2019Article
- Characterization of theThe Journal of biological chemistry · 2018Article
- Metabolic Reprogramming of Vibrio cholerae Impaired in Respiratory NADH Oxidation Is Accompanied by Increased Copper Sensitivity.Journal of bacteriology · 2018Article
- Serine 26 in the PomB subunit of the flagellar motor is essential for hypermotility of Vibrio cholerae.PloS one · 2015Article
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
The Na+ translocating NADH:quinone oxidoreductase (Na+-NQR) is a unique respiratory enzyme catalyzing the electron transfer from NADH to quinone coupled with the translocation of sodium ions across the membrane. Typically, Vibrio spp., including Vibrio cholerae, have this enzyme but lack the proton-pumping NADH:ubiquinone oxidoreductase (Complex I). Thus, Na+-NQR should significantly contribute to multiple aspects of V. cholerae physiology; however, no detailed characterization of this aspect has been reported so far. In this study, we broadly investigated the effects of loss of Na+-NQR on V. cholerae physiology by using Phenotype Microarray (Biolog), transcriptome and metabolomics analyses. We found that the V. cholerae ΔnqrA-F mutant showed multiple defects in metabolism detected by Phenotype Microarray. Transcriptome analysis revealed that the V. cholerae ΔnqrA-F mutant up-regulates 31 genes and down-regulates 55 genes in both early and mid-growth phases. The most up-regulated genes included the cadA and cadB genes, encoding a lysine decarboxylase and a lysine/cadaverine antiporter, respectively. Increased CadAB activity was further suggested by the metabolomics analysis. The down-regulated genes include sialic acid catabolism genes. Metabolomic analysis also suggested increased reductive pathway of TCA cycle and decreased purine metabolism in the V. cholerae ΔnqrA-F mutant. Lack of Na+-NQR did not affect any of the Na+ pumping-related phenotypes of V. cholerae suggesting that other secondary Na+ pump(s) can compensate for Na+ pumping activity of Na+-NQR. Overall, our study provides important insights into the contribution of Na+-NQR to V. cholerae physiology.
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