ArticlePloS one2014
Prognostic value of the lymph node ratio in stage III gastric cancer patients undergoing radical resection.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Article
- Lymph Node Ratio as a Risk Factor for Early Recurrence in Older Patients with Stage II/III Gastric Cancer: A Retrospective Study.Journal of clinical medicine · 2025Article
- Evaluation of lymph node ratios and log odds of positive nodes as prognostic indicators in primary organ malignancy.Medical journal, Armed Forces India · 2025Article
- Prognostic significance of lymph node ratio in esophageal squamous cell carcinoma: insights from the South Asian population.Frontiers in oncology · 2024Article
- Evaluation of Four Lymph Node Classifications for the Prediction of Survival in Hilar Cholangiocarcinoma.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022Article
- Value of the log odds of positive lymph nodes for prognostic assessment of colon mucinous adenocarcinoma: Analysis and external validation.Cancer medicine · 2021Article
- Article
- Prognostic Significance of Metastatic Lymph Nodes Ratio (MLNR) Combined with Protein-Tyrosine Phosphatase H1 (PTPH1) Expression in Operable Breast Invasive Ductal Carcinoma.Cancer management and research · 2020Article
- Prognostic analysis of stage III gastric cancer after curative surgery according to the newest TNM classification.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2019Article
- Comparison of the 8th union for international cancer control lymph node staging system for gastric cancer with two other lymph node staging systems.Oncology letters · 2019Article
- The association of the lymph node ratio and serum carbohydrate antigen 19-9 with early recurrence after curative gastrectomy for gastric cancer.Surgery today · 2018Article
- Prognostic value of number of negative lymph node in patients with stage II and IIIa non-small cell lung cancer.Oncotarget · 2017Article
- Outcome and evaluation of prognostic factors after pancreaticoduodenectomy for distal cholangiocarcinoma.Annals of gastroenterology · 2017Article
- Different lymph node staging systems in patients with gastric cancer from Korean: What is the best prognostic assessment tool?Medicine · 2016Observational
- Article
- Adjuvant radiochemotherapy for gastric cancer: Should we use prognostic factors to select patients?World journal of gastroenterology · 2016Review
- Clinical significance of accurate identification of lymph node status in distant metastatic gastric cancer.Oncotarget · 2016Article
- Prognostic significance of metastatic lymph node ratio in squamous cell carcinoma of the cervix.OncoTargets and therapy · 2016Article
- Prognostic significance of lymph node ratio in esophageal cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
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6 authors.
Funding
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Abstract
objectiveThe aim of this study was to investigate the prognostic value of metastatic lymph node ratio (LNR) in patients having radical resection for stage III gastric cancer.
methodsA total of 365 patients with stage III gastric cancer who underwent radical resection between 2002 and 2008 at Tianjin Medical University Cancer Institute and Hospital were analyzed. The cut-point survival analysis was adopted to determine the appropriate cutoffs for LNR. Kaplan-Meier survival curves and log-rank tests were used for the survival analysis.
resultsBy cut-point survival analysis, the LNR staging system was generated using 0.25 and 0.50 as the cutoff values. Pearson's correlation test revealed that the LNR was related with metastatic lymph nodes but not related with total harvested lymph nodes. Cox regression analysis showed that depth of invasion and LNR were the independent predictors of survival (p<0.05). There was a significant difference in survival between each pN stages classified by the LNR staging, however no significant difference was found in survival rate between each LNR stages classified by the pN staging.
conclusionsThe LNR is an independent prognostic factor for survival in stage III gastric cancer and is superior to the pN category in TNM staging. It may be considered as a prognostic variable in future staging system.
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