ArticleDigestive diseases and sciences2014
GERD symptoms in the general population: prevalence and severity versus care-seeking patients.
Article in Digestive diseases and sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Lansoprazole for persistent throat symptoms in secondary care: the TOPPITS RCT.Health technology assessment (Winchester, England) · 2021Trial
- Trial
- Perceived stress, diet, and medication use associated with GERD symptoms in Lebanese adults: A cross-sectional study.Journal of public health research · 2026Article
- Article
- Disease Burden and Treatment Patterns Associated With Eosinophilic Esophagitis in the United States: A Retrospective Claims Study.Journal of clinical gastroenterology · 2022Article
- Non-surgical animal model of gastroesophageal reflux disease by overeating induced in mice.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2021Article
- Esophageal hypervigilance is prevalent across gastroesophageal reflux disease presentations.Neurogastroenterology and motility · 2021Article
- Are Anxious and Depressive Symptoms Associated with Gastrointestinal Symptoms in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)?Journal of racial and ethnic health disparities · 2021Article
- Management of gastroesophageal reflux disease: Patient and physician communication challenges and shared decision making.World journal of clinical cases · 2018Review
- Use of online symptom checkers to delineate the ever-elusive GERD versus non-GERD cough.The clinical respiratory journal · 2018Article
- Epidemiology of gastrointestinal symptoms in young and middle-aged Swiss adults: prevalences and comorbidities in a longitudinal population cohort over 28 years.BMC gastroenterology · 2018Article
- Diet and Rheumatoid Arthritis Symptoms: Survey Results From a Rheumatoid Arthritis Registry.Arthritis care & research · 2017Article
- Diagnosis and management of treatment-refractory hypothyroidism: an expert consensus report.Journal of endocrinological investigation · 2017Review
- Dietary habits and obesity indices in patients with gastro-esophageal reflux disease: a comparative cross-sectional study.BMC gastroenterology · 2017Article
- Integrative Medicine for Gastrointestinal Disease.Primary care · 2017Review
- Gastrointestinal symptom severity in irritable bowel syndrome, inflammatory bowel disease and the general population.Neurogastroenterology and motility · 2017Article
- Tri-comparison of Laparoscopic Nissen, Hill, and Nissen-Hill Hybrid Repairs for Uncomplicated Gastroesophageal Reflux Disease.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2017Article
- Characterization of Mast Cell Activation Syndrome.The American journal of the medical sciences · 2017Article
- The Economic Impact of Levothyroxine Dose Adjustments: the CONTROL HE Study.Clinical drug investigation · 2017Article
- Hiatal hernia and gastroesophageal reflux: Study of collagen in the phrenoesophageal ligament.Surgical endoscopy · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundPrior estimates suggest that up to 40% of the US general population (GP) report symptoms of gastroesophageal reflux disease (GERD). However, symptoms in the GP versus patients seeking care for gastrointestinal (GI) complaints have not been compared. We estimated the prevalence and severity of GERD symptoms in the GP versus GI patients, and identified predictors of GERD severity. We hypothesized that similar to functional GI disorders, psychosocial factors would predict symptom severity in GERD as much, or perhaps more, than care-seeking behavior alone.
methodsWe compared the prevalence of heartburn and regurgitation between a sample from the US GP and patients seeking GI specialty care. We compared GERD severity between groups using the NIH PROMIS(®) GERD scale. We then performed multivariable regression to identify predictors of GERD severity.
resultsThere was no difference in the prevalence of heartburn between the GP and patient groups (59 vs. 59%), but regurgitation was more common in patients versus GP (46 vs. 39%; p = 0.004). In multivariable regression, having high visceral anxiety (p < 0.001) and being divorced or separated (p = 0.006) were associated with higher GERD severity.
conclusionsMore than half of a GP sample reports heartburn-higher than previous series and no different from GI patients. Although regurgitation was more prevalent in patients versus the GP, there was no difference in GERD severity between groups after adjusting for other factors; care seeking in GERD appears related to factors beyond symptoms, including visceral anxiety.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.