SynthesisCyberpsychology, behavior and social networking2014
Game-based digital interventions for depression therapy: a systematic review and meta-analysis.
Synthesis in Cyberpsychology, behavior and social networking, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 83 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Effectiveness of the "VRTierOne" Virtual Therapeutic Game as a Method Supporting the Post-stroke Rehabilitation
Evaluation of the Effectiveness of Immersive Virtual Reality Therapy as a Method Supporting the Cardiac Rehabilitation
Immersive Virtual Therapy as a Method Supporting the Non-Farmacological Treatment of Late-Life Depression
The Evaluation of Virtual Reality Therapy Efficacy in the Treatment of Depressive and Anxiety Symptoms in Patients With Coronary Artery Disease
Who cites it
83 citing papers in PubMed, 4 syntheses or guidelines pooled it, 235 citations in OpenAlex.
- The use of games in the classroom to promote mental health knowledge and healthy attitudes in adolescents: a systematic review.Frontiers in psychiatry · 2025Pooled it
- Providing Human Support for the Use of Digital Mental Health Interventions: Systematic Meta-review.Journal of medical Internet research · 2023Pooled it
- Effects of Serious Games on Depression in Older Adults: Systematic Review and Meta-analysis of Randomized Controlled Trials.Journal of medical Internet research · 2022Pooled it
- The relationship between screen-based sedentary behaviors and symptoms of depression and anxiety in youth: a systematic review of moderating variables.BMC public health · 2020Pooled it
- Virtual reality as a promising method of pain relief in patients with venous leg ulcers.International wound journal · 2024Trial
- Effectiveness of a Web-Based Individual Coping and Alcohol Intervention Program for Children of Parents With Alcohol Use Problems: Randomized Controlled Trial.Journal of medical Internet research · 2024Trial
- Effects of a Digital Mental Health Intervention on Perceived Stress and Rumination in Adolescents Aged 13 to 17 Years: Randomized Controlled Trial.Journal of medical Internet research · 2024Trial
- Article
- Exploring Serious Games in Supporting Postnatal Depression: Narrative Review.Interactive journal of medical research · 2026Review
- The Role of Temporality in Virtual Reality Interventions for Depressive Episodes-A Scoping Review.Healthcare (Basel, Switzerland) · 2026Review
- Digital Humans for Depression Assessment and Intervention Support: Scoping Review.JMIR mental health · 2026Article
- A Novel Macro-Level Model in Evaluating Health and Safety Training Based on Virtual Reality.International journal of environmental research and public health · 2025Article
- Efficacy of Motion-Sensing Game-Assisted Pulmonary Rehabilitation in Patients With Chronic Obstructive Pulmonary Disease: Systematic Review and Meta-Analysis of Randomized Controlled Trials.JMIR serious games · 2025Review
- Game-Based Digital Interventions for Enhancing Positive Development and Addressing Substance Use in Adolescents: A Systematic Review.Children (Basel, Switzerland) · 2024Review
- Exploring Participants' Experiences of Digital Health Interventions With Qualitative Methods: Guidance for Researchers.Journal of medical Internet research · 2024Article
- Cognitive rehabilitation in bipolar spectrum disorder: A systematic review.IBRO neuroscience reports · 2024Review
- Learnings From Implementation of Technology-Enabled Mental Health Interventions in India: Implementation Report.JMIR medical informatics · 2024Article
- A comparison between effects of sudoku and mandala painting on anxiety of breast cancer patients undergoing chemotherapy.Journal of family medicine and primary care · 2024Article
- Smartphone-based serious games for mental health: a scoping review.Multimedia tools and applications · 2024Article
- The effects of interactive video games combined with LEGO game therapy on social anxiety in rural left-behind children.Frontiers in psychology · 2024Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to review the existing literature on game-based digital interventions for depression systematically and examine their effectiveness through a meta-analysis of randomized controlled trials (RCTs). Database searching was conducted using specific search terms and inclusion criteria. A standard meta-analysis was also conducted of available RCT studies with a random effects model. The standard mean difference (Cohen's d) was used to calculate the effect size of each study. Nineteen studies were included in the review, and 10 RCTs (eight studies) were included in the meta-analysis. Four types of game interventions-psycho-education and training, virtual reality exposure therapy, exercising, and entertainment-were identified, with various types of support delivered and populations targeted. The meta-analysis revealed a moderate effect size of the game interventions for depression therapy at posttreatment (d=-0.47 [95% CI -0.69 to -0.24]). A subgroup analysis showed that interventions based on psycho-education and training had a smaller effect than those based on the other forms, and that self-help interventions yielded better outcomes than supported interventions. A higher effect was achieved when a waiting list was used as the control. The review and meta-analysis support the effectiveness of game-based digital interventions for depression. More large-scale, high-quality RCT studies with sufficient long-term data for treatment evaluation are needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.