ArticlePloS one2014
Heterogeneity of host TLR2 stimulation by Staphylocoocus aureus isolates.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Review
- Toll-like receptor 2 downregulation and cytokine dysregulation predict mortality in patients with Staphylococcus aureus bacteremia.BMC infectious diseases · 2020Article
- LipoproteinmBio · 2020Article
- "Gene accordions" cause genotypic and phenotypic heterogeneity in clonal populations of Staphylococcus aureus.Nature communications · 2020Article
- Activation of IL-10+ B cells: A novel immunomodulatory mechanism for therapeutic bacterial suspensions.SAGE open medicine · 2020Article
- Click-to-Capture: A method for enriching viable Staphylococcus aureus using bio-orthogonal labeling of surface proteins.PloS one · 2020Article
- Activation of a Bovine Mammary Epithelial Cell Line by Ruminant-AssociatedMicroorganisms · 2019Article
- The in vitro host cell immune response to bovine-adapted Staphylococcus aureus varies according to bacterial lineage.Scientific reports · 2019Article
- Differential Responses of Human Dendritic Cells to Live or InactivatedFrontiers in immunology · 2019Article
- Article
- After the deluge: mining Staphylococcus aureus genomic data for clinical associations and host-pathogen interactions.Current opinion in microbiology · 2018Review
- Inflammatory properties of antibiotic-treated bacteria.Journal of leukocyte biology · 2017Review
- Mechanical Ventilation Alters the Development of Staphylococcus aureus Pneumonia in Rabbit.PloS one · 2016Article
- Uncoupling of pro- and anti-inflammatory properties of Staphylococcus aureus.Infection and immunity · 2015Article
- Enterococcus faecalis Glycolipids Modulate Lipoprotein-Content of the Bacterial Cell Membrane and Host Immune Response.PloS one · 2015Article
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High lipoprotein expression and potent activation of host Toll-like receptor-2 (TLR2) are characteristic features of the staphylococcal species. Expression of TLR2 in the host is important for clearance of Staphylococcus aureus infection and host survival. Thus, we hypothesized that bacterial regulation of its intrinsic TLR2-stimulatory capacity could represent a means for immune evasion or host adaptation. We, therefore, compared clinical S. aureus isolates in regards to their TLR2 activation potential and assessed the bacterial factors that modulate TLR2-mediated recognition. S. aureus isolates displayed considerable variability in TLR2-activity with low to absent TLR2-activity in 64% of the isolates tested (68/106). Notably, strain-specific TLR2-activity was independent of the strain origin, e.g. no differences were found between strains isolated from respiratory specimen from cystic fibrosis patients or those isolated from invasive disease specimen. TLR2-activity correlated with protein A expression but not with the agr status. Capsule expression and small colony variant formation had a negative impact on TLR2-activity but any disruption of cell wall integrity enhanced TLR2 activation. Altogether, heterogeneity in host TLR2-activity reflects differences in metabolic activity and cell wall synthesis and/or remodeling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.