ArticlePloS one2014
Renal function in children suffering from sickle cell disease: challenge of early detection in highly resource-scarce settings.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Liver and renal biochemical profiles of people with sickle cell disease in Africa: a systematic review and meta-analysis of case-control studies.Systematic reviews · 2024Pooled it
- Ambulatory blood pressure abnormalities, obstructive sleep apnea, and end-organ damage in children with sickle cell disease.Pediatric nephrology (Berlin, Germany) · 2026Article
- Article
- Hydroxyurea and Regression of Sickle Cell Nephropathy: Open Clinical Trial in a Pediatric Population in Democratic Republic of Congo.Kidney360 · 2025Article
- Microalbuminuria in Children With Sickle Cell Disease in the Eastern Province of Saudi Arabia.Cureus · 2024Article
- Glomerular hyperfiltration: part 2-clinical significance in children.Pediatric nephrology (Berlin, Germany) · 2023Review
- Article
- Renal Abnormalities among Sickle Cell Disease Patients in a Poor Management Setting: A Survey in the Democratic Republic of the Congo.Mediterranean journal of hematology and infectious diseases · 2022Article
- Glomerular filtration rate abnormalities in sickle cell disease.Frontiers in medicine · 2022Review
- Abnormal Ambulatory Blood Pressure and Early Renal Dysfunction in Sickle Cell Disease.Indian journal of pediatrics · 2021Article
- Assessment of Renal Function Status in Steady-State Sickle Cell Anaemic Children Using Urine Human Neutrophil Gelatinase-Associated Lipocalin and Albumin:Creatinine Ratio.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2021Article
- Association between Endothelial Dysfunction, Biomarkers of Renal Function, and Disease Severity in Sickle Cell Disease.Kidney360 · 2020Article
- Association between renal function parameters, clinical severity score and mortality risk among adult Sudanese sickle anemia patients.American journal of blood research · 2020Article
- Sickle Cell Nephropathy and Associated Factors among Asymptomatic Children with Sickle Cell Anaemia.International journal of pediatrics · 2020Article
- Prevalence and factors associated with renal dysfunction in children admitted to two hospitals in northwestern Tanzania.BMC nephrology · 2019Article
- Biochemical effects and safety of Gum arabic (Blood research · 2019Article
- Article
- Chronic Kidney Disease amongst Sickle Cell Anaemia Patients at the University of Maiduguri Teaching Hospital, Northeastern Nigeria: A Study of Prevalence and Risk Factors.Mediterranean journal of hematology and infectious diseases · 2019Article
- Clinical phenotypes and the biological parameters of Congolese patients suffering from sickle cell anemia: A first report from Central Africa.Journal of clinical laboratory analysis · 2017Article
- Evaluating risk factors for chronic kidney disease in pediatric patients with sickle cell anemia.Pediatric nephrology (Berlin, Germany) · 2017Observational
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prevalence of Sickle cell disease is extremely high in Democratic Republic of Congo. Despite this high prevalence of the disease, data on renal abnormalities in children are rare.
methodThe study proposed to assess blood pressure, glomerular function, urea and uric acid levels in 65 steady state Congolese children with homozygous sickle cell disease and 67 normal controls.
resultsIn Hb-SS group, blood pressure level tended to be lower than Hb-AA groups but there was no statistically significant difference (p>0.05) between the two groups. The absolute values for GFR corrected for BSA were significantly higher in Hb-SS group compared to Hb-AA group (130.5±34.1 ml/min/1.73 m2 vs 113.7±24.5 ml/min/1.73 m2; p = 0.004). Children with Hb-SS were more likely to hyperfiltrate (30.8% of subjects) than children with Hb-AA (6.1% of subjects). Proteinuria was found in 4 (6.2%) children with Hb-SS. Uric acid level was significantly increased in children with Hb-SS compared to corresponding values in control group (4.4±1.3 mg/dl vs 3.5±1.1 mg/dl; p<0.001). Urea level was significantly decreased compared to corresponding values in Hb-AA group (15.3±8.3 mg/dl vs 22.9±10.1 mg/dl; p<0.001).
conclusionHyperfiltration, low creatinine, lower urea and high uric acid are more common in children with sickle cell disease than in normal controls.
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