ArticleSubstance use & misuse2014
Volume and type of alcohol during early pregnancy and the risk of miscarriage.
Article in Substance use & misuse, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- eHealth Interventions to Treat Substance Use in Pregnancy: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- A Review on the Vagus Nerve and Autonomic Nervous System During Fetal Development: Searching for Critical Windows.Frontiers in neuroscience · 2021Pooled it
- Alcohol Use in Pregnancy and Miscarriage: A Systematic Review and Meta-Analysis.Alcoholism, clinical and experimental research · 2019Pooled it
- Association of maternal alcohol consumption with frequent nocturnal enuresis in offspring.European child & adolescent psychiatry · 2026Article
- Prenatal ethanol exposure and changes in fetal neuroendocrine metabolic programming.Biological research · 2023Review
- Time-Varying Exposures and Miscarriage: A Comparison of Statistical Models Through Simulation.American journal of epidemiology · 2023Article
- Involvement of metalloproteinase and nitric oxide synthase/nitric oxide mechanisms in early decidual angiogenesis-vascularization of normal and experimental pathological mouse placenta related to maternal alcohol exposure.Frontiers in cell and developmental biology · 2023Review
- The effect of paternal and maternal factors on the prognosis of live birth in couples with recurrent pregnancy loss.Acta obstetricia et gynecologica Scandinavica · 2022Article
- Feasibility of continuous distal body temperature for passive, early pregnancy detection.PLOS digital health · 2022Article
- Risk score to stratify miscarriage risk levels in preconception women.Scientific reports · 2021Article
- Early Abnormal Placentation and Evidence of Vascular Endothelial Growth Factor System Dysregulation at the Feto-Maternal Interface After Periconceptional Alcohol Consumption.Frontiers in physiology · 2021Review
- Differentially sensitive neuronal subpopulations in the central nervous system and the formation of hindbrain heterotopias in ethanol-exposed zebrafish.Birth defects research · 2019Article
- Prenatal Alcohol Exposure, Anesthesia, and Fetal Loss in Baboon Model of Pregnancy.Journal of drug and alcohol research · 2018Article
- Substance use in pregnancy: The medical challenge.Obstetric medicine · 2018Review
- Prevalence of alcohol use in pregnant women with substance use disorder.Drug and alcohol dependence · 2018Article
- ESHRE guideline: recurrent pregnancy loss.Human reproduction open · 2018Article
- The impact of maternal factors on the association between temperature and preterm delivery.Environmental research · 2017Article
- Factors associated with spontaneous abortion: a cross-sectional study of Chinese populations.Reproductive health · 2017Article
- What the Spectrum of Microglial Functions Can Teach us About Fetal Alcohol Spectrum Disorder.Frontiers in synaptic neuroscience · 2017Review
- Alcohol and fertility: how much is too much?Fertility research and practice · 2017Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundResearch on alcohol consumption during pregnancy and miscarriage spans over three decades, yet the relationship is still not well-understood.
objectivesTo assess the relationship between volume and type of alcohol consumed during pregnancy in relation to miscarriage.
methodsWe utilized data from a population-based cohort study of pregnant women (n = 1061) of which 172 (16%) women had a miscarriage. Upon study entry, participants were asked about their alcohol consumption during pregnancy. Based on the average number of drinks per week, women were categorized into one of three categories: four or more drinks per week (n = 32, 3%), less than four drinks per week (n = 403, 38%), and no alcohol intake (n = 626, 59%). In addition, women were categorized by the type of alcohol beverage they consumed: beer only (n = 47, 4%), spirits only (n = 56, 5%), wine only (n = 160, 15%), or a combination of two or more types of alcohol (n = 172, 16%).
resultsA significant increased risk of miscarriage (adjusted hazard ratio (aHR): 2.65; 95% confidence interval (CI): 1.38, 5.10) was found for women who drank four or more drinks a week. Our findings also suggest the relationship between alcohol intake during pregnancy and miscarriage is strongest for miscarriage occurring prior to 10 weeks of gestation. In addition, women who drank only spirits had more than a two-fold increased risk of miscarriage compared to women who abstained (aHR: 2.24; 95% CI: 1.32, 3.81). Conclusions/Importance: Future research assessing the factors that may contribute to an increased risk of miscarriage should consider the type of alcohol consumed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.