Evidence map›Paper›PMID 24810274›Full record

ArticleJournal of dental research2014

Genetic Association of MPPED2 and ACTN2 with Dental Caries.

B O C Stanley, E Feingold, M Cooper, M M Vanyukov, B S Maher, R L Slayton, M C Willing, S E Reis, D W McNeil, R J Crout and 5 more

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
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  10. Article
  11. Genetic Association ofInternational journal of dentistry · 2017
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. [Precision stomatology: current status and challenges].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

B O C StanleyDepartment of Mathematics, Vanderbilt University, Nashville, TN, USA.
E FeingoldDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
M CooperCenter for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
M M VanyukovDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
B S MaherDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, USA.
R L SlaytonDepartment of Pediatric Dentistry, School of Dentistry, University of Washington, Seattle, WA, USA.
M C WillingDivision of Genetics and Genomics, Medicine, Department of Pediatrics, School of Medicine, Washington, University at St. Louis, St. Louis, MO, USA.
S E ReisDepartment of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA Clinical and Translational Science Institute, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
D W McNeilDental Practice and Rural Health, West Virginia University, Morgantown, WV, USA.
R J CroutDepartment of Periodontics, School of Dentistry, West Virginia University, Morgantown, WV, USA.
R J WeyantDepartment of Dental Public Health and Information Management, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
S M LevyDepartment of Preventive and Community Dentistry, University of Iowa College of Dentistry, Iowa City, IA, USA Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, USA.
A R VieiraCenter for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
M L MarazitaDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA Clinical and Translational Science Institute, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
J R ShafferDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA jrs51@pitt.edu.
University of Pittsburgh · USWest Virginia University · USJohns Hopkins University · USUniversity of Iowa · USUniversity of Washington · USVanderbilt University · US

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Psychosocial Influences on Rural Children's Oral HealthR01DE014899 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FOXMAN, BETSY, MARAZITA, MARY L. · 2002 to 2020
$39.9M
TRANSLATION MODULEP50DA005605 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RIDENOUR, TY A · 1989 to 2014
$25.7M
Fluoride & Other Factors in Childhood and Adolescent Bone DevelopmentR01DE012101 · NIDCR · UNIVERSITY OF IOWA · PI LEVY, STEVEN M. · 1998 to 2013
$11.9M
LONGITUDINAL STUDY OF FLUORIDE EXPOSURES &FLUORIDER01DE009551 · NIDCR · UNIVERSITY OF IOWA · PI LEVY, STEVEN M. · 1991 to 2008
$4.7M
Genetics of CariesR01DE018914 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VIEIRA, ALEXANDRE REZENDE · 2009 to 2013
$2.2M
Substance Use Disorder Liability: Candidate Gene SystemR01DA019157 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VANYUKOV, MICHAEL M · 2004 to 2008
$2.2M
Dental Caries: Whole Genome Association and Gene x Environment StudiesU01DE018903 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARAZITA, MARY L. · 2007 to 2010
$1.2M
NCATS NIH HHS UL1 TR000005NIDA NIH HHS P50 DA005605NIDA NIH HHS P50-DA005605NIDA NIH HHS R01 DA019157NIDA NIH HHS R01-DA019157NIDCR NIH HHS R01 DE009551NIDCR NIH HHS R01-DE009551NIDCR NIH HHS R01 DE012101NIDCR NIH HHS R01-DE012101NIDCR NIH HHS R01 DE014899NIDCR NIH HHS R01-DE014899NIDCR NIH HHS R01 DE018914NIDCR NIH HHS R01-DE018914NIDCR NIH HHS U01 DE018903NIDCR NIH HHS U01-DE018903
6 · The paper itself

Abstract

The first genome-wide association study of dental caries focused on primary teeth in children aged 3 to 12 yr and nominated several novel genes: ACTN2, EDARADD, EPHA7, LPO, MPPED2, MTR, and ZMPSTE24. Here we interrogated 156 single-nucleotide polymorphisms (SNPs) within these candidate genes for evidence of association with dental caries experience in 13 race- and age-stratified samples from 6 independent studies (n = 3600). Analysis was performed separately for each sample, and results were combined across samples via meta-analysis. MPPED2 was significantly associated with caries via meta-analysis across the 5 childhood samples, with 4 SNPs showing significant associations after gene-wise adjustment for multiple comparisons (p < .0026). These results corroborate the previous genome-wide association study, although the functional role of MPPED2 in caries etiology remains unknown. ACTN2 also showed significant association via meta-analysis across childhood samples (p = .0014). Moreover, in adults, genetic association was observed for ACTN2 SNPs in individual samples (p < .0025), but no single SNP was significant via meta-analysis across all 8 adult samples. Given its compelling biological role in organizing ameloblasts during amelogenesis, this study strengthens the hypothesis that ACTN2 influences caries risk. Results for the other candidate genes neither proved nor precluded their associations with dental caries.

Indexed as

5-Methyltetrahydrofolate-Homocysteine S-MethyltransferaseActininAdolescentAdultAmelogenesisBlack or African AmericanChildChild, PreschoolDental CariesEdar-Associated Death Domain ProteinFemaleGenome-Wide Association StudyHumansLipoproteinsMaleMembrane Proteins5-Methyltetrahydrofolate-Homocysteine S-MethyltransferaseActininACTN2 protein, humanEdar-Associated Death Domain ProteinLipoproteinsMembrane ProteinsMetalloendopeptidasesMPPED2 protein, humanMTR protein, humanPhosphoric Diester HydrolasesReceptor, EphA7ZMPSTE24 protein, humanEDARADDEPHA7LPOMTRsingle nucleotide polymorphismZMPSTE24

Identifiers

PMID24810274
PMCPMC4107549
OpenAlexW1967099533

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.