ArticleJournal of biomedical optics2014
Optical coherence tomography microangiography for monitoring the response of vascular perfusion to external pressure on human skin tissue.
Article in Journal of biomedical optics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Observation on the efficacy of skin closure by skin staplers in extended L-shaped incisions for calcaneal fractures.Journal of orthopaedic surgery and research · 2026Trial
- Effects of loading and prophylactic dressings on the sacral and heel skin: An exploratory cross-over trial.International wound journal · 2021Trial
- Flexible thermal array sensor for imperceptible monitoring of multidimensional vascular dynamics.Science advances · 2026Article
- Quantitative Optimization of Handheld Probe External Pressure on Dermatological Microvasculature Using Optical Coherence Tomography-Based Angiography.Micromachines · 2024Article
- Comparative study of OCTA algorithms with a high-sensitivity multi-contrast Jones matrix OCT system for human skin imaging.Biomedical optics express · 2022Article
- High resolution imaging and quantification of the nailfold microvasculature using optical coherence tomography angiography (OCTA) and capillaroscopy: a preliminary study in healthy subjects.Quantitative imaging in medicine and surgery · 2022Article
- The application of SFDI and LSI system to evaluate the blood perfusion in skin flap mouse model.Lasers in medical science · 2022Article
- High-resolution functional photoacoustic monitoring of vascular dynamics in human fingers.Photoacoustics · 2021Article
- Automatic 3D adaptive vessel segmentation based on linear relationship between intensity and complex-decorrelation in optical coherence tomography angiography.Quantitative imaging in medicine and surgery · 2021Article
- Assessment of chronic radiation proctopathy and radiofrequency ablation treatment follow-up with optical coherence tomography angiography: A pilot study.World journal of gastroenterology · 2019Observational
- Optical coherence tomography angiography for noninvasive evaluation of angiogenesis in a limb ischemia mouse model.Scientific reports · 2019Article
- Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts.Nature communications · 2019Article
- Short-time series optical coherence tomography angiography and its application to cutaneous microvasculature.Biomedical optics express · 2019Article
- Handheld optical palpation of turbid tissue with motion-artifact correction.Biomedical optics express · 2019Article
- Quantitative characterization of mechanically indented in vivo human skin in adults and infants using optical coherence tomography.Journal of biomedical optics · 2017Article
- In vivo photoacoustic microscopy of human cuticle microvasculature with single-cell resolution.Journal of biomedical optics · 2016Article
- Minimizing projection artifacts for accurate presentation of choroidal neovascularization in OCT micro-angiography.Biomedical optics express · 2015Article
- In vivo dual-modality photoacoustic and optical coherence tomography imaging of human dermatological pathologies.Biomedical optics express · 2015Article
- In vivo imaging of functional microvasculature within tissue beds of oral and nasal cavities by swept-source optical coherence tomography with a forward/side-viewing probe.Biomedical optics express · 2014Article
- Assessment of microcirculation dynamics during cutaneous wound healing phases in vivo using optical microangiography.Journal of biomedical optics · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Characterization of the relationship between external pressure and blood flow is important in the examination of pressure-induced disturbance in tissue microcirculation. Optical coherence tomography (OCT)-based microangiography is a promising imaging technique, capable of providing the noninvasive extraction of functional vessels within the skin tissue with capillary-scale resolution. Here, we present a feasibility study of OCT microangiography (OMAG) to evaluate changes in blood perfusion in response to externally applied pressure on human skin tissue in vivo. External force is loaded normal to the tissue surface at the nailfold region of a healthy human volunteer. An incremental force is applied step by step and then followed by an immediate release. Skin perfusion events including baseline are continuously imaged by OMAG, allowing for visualization and quantification of the capillary perfusion in the nailfold tissue. The tissue strain maps are simultaneously evaluated through the available OCT structural images to assess the relationship of the microcirculation response to the applied pressure. The results indicate that the perfusion progressively decreases with the constant increase of pressure. Reactive hyperemia occurs right after the removal of the pressure. The perfusion returns to the baseline level after a few minutes. These findings suggest that OMAG may have great potential for quantitatively assessing tissue microcirculation in the locally pressed tissue in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.