ArticleDevelopmental biology2014
Sema3A maintains corneal avascularity during development by inhibiting Vegf induced angioblast migration.
Article in Developmental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Neutrophil pyroptosis regulates corneal wound healing and post-injury neovascularisation.Clinical and translational medicine · 2024Article
- Expression of Nephronectin in the Descemet's membrane of mouse corneas during development and adult homeostasis.Experimental eye research · 2024Article
- Expression of axon guidance ligands and their receptors in the cornea and trigeminal ganglia and their recovery after corneal epithelium injury.Experimental eye research · 2022Article
- miR-23a-3p is a Key Regulator of IL-17C-Induced Tumor Angiogenesis in Colorectal Cancer.Cells · 2020Article
- Endothelial cells on the move: dynamics in vascular morphogenesis and disease.Vascular biology (Bristol, England) · 2020Review
- Primary cilia deficiency in neural crest cells models anterior segment dysgenesis in mouse.eLife · 2019Article
- Semaphorin 3A gets involved in the establishment of mouse tooth eruptive pathway.Journal of molecular histology · 2019Article
- Wnt Signaling in vascular eye diseases.Progress in retinal and eye research · 2019Review
- In vivo topology converts competition for cell-matrix adhesion into directional migration.Nature communications · 2019Article
- Transformation of the Transcriptomic Profile of Mouse Periocular Mesenchyme During Formation of the Embryonic Cornea.Investigative ophthalmology & visual science · 2019Article
- Alterations in Corneal Sensory Nerves During Homeostasis, Aging, and After Injury in Mice Lacking the Heparan Sulfate Proteoglycan Syndecan-1.Investigative ophthalmology & visual science · 2017Article
- Building branched tissue structures: from single cell guidance to coordinated construction.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Knockdown of CXCL14 disrupts neurovascular patterning during ocular development.Developmental biology · 2017Article
- It Takes Two to Tango: Coupling of Angiogenesis and Osteogenesis for Bone Regeneration.Frontiers in bioengineering and biotechnology · 2017Review
- The Role of Semaphorin 3A in Bone Remodeling.Frontiers in cellular neuroscience · 2017Review
- Pias1 is essential for erythroid and vascular development in the mouse embryo.Developmental biology · 2016Article
- PlexinD1 is required for proper patterning of the periocular vascular network and for the establishment of corneal avascularity during avian ocular development.Developmental biology · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Corneal avascularity is important for optical clarity and normal vision. However, the molecular mechanisms that prevent angioblast migration and vascularization of the developing cornea are not clear. Previously we showed that periocular angioblasts and forming ocular blood vessels avoid the presumptive cornea despite dynamic ingression of neural crest cells. In the current study, we investigate the role of Semaphorin3A (Sema3A), a cell guidance chemorepellent, on angioblast migration and corneal avascularity during development. We show that Sema3A, Vegf, and Nrp1 are expressed in the anterior eye during cornea development. Sema3A mRNA transcripts are expressed at significantly higher levels than Vegf in the lens that is positioned adjacent to the presumptive cornea. Blockade of Sema3A signaling via lens removal or injection of a synthetic Sema3A inhibitor causes ectopic migration of angioblasts into the cornea and results in its subsequent vascularization. In addition, using bead implantation, we demonstrate that exogenous Sema3A protein inhibits Vegf-induced vascularization of the cornea. In agreement with these findings, loss of Sema/Nrp1 signaling in Nrp1(Sema-) mutant mice results in ectopic angioblasts and vascularization of the embryonic mouse corneas. Altogether, our results reveal Sema3A signaling as an important cue during the establishment of corneal avascularity in both chick and mouse embryos. Our study introduces cornea development as a new model for studying the mechanisms involved in vascular patterning during embryogenesis and it also provides new insights into therapeutic potential for Sema3A in neovascular diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.