ArticleAnnals of biomedical engineering2014
Ex vivo lymphatic perfusion system for independently controlling pressure gradient and transmural pressure in isolated vessels.
Article in Annals of biomedical engineering, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Mimicking blood and lymphatic vasculatures using microfluidic systems.Biomicrofluidics · 2024Review
- An adaptable research platform for ex vivo normothermic machine perfusion of the liver.International journal of computer assisted radiology and surgery · 2023Article
- Lymphatic-draining nanoparticles deliver Bay K8644 payload to lymphatic vessels and enhance their pumping function.Science advances · 2023Article
- Lymphatic remodelling in response to lymphatic injury in the hind limbs of sheep.Nature biomedical engineering · 2020Article
- The Biophysics of Lymphatic Transport: Engineering Tools and Immunological Consequences.iScience · 2019Review
- Entrainment of Lymphatic Contraction to Oscillatory Flow.Scientific reports · 2019Article
- Experimental Models Used to Assess Lymphatic Contractile Function.Lymphatic research and biology · 2017Review
- A lumped parameter model of mechanically mediated acute and long-term adaptations of contractility and geometry in lymphatics for characterization of lymphedema.Biomechanics and modeling in mechanobiology · 2016Article
- The Lymphatic System in Disease Processes and Cancer Progression.Annual review of biomedical engineering · 2016Review
- Postprandial lymphatic pump function after a high-fat meal: a characterization of contractility, flow, and viscosity.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- Effects of dynamic shear and transmural pressure on wall shear stress sensitivity in collecting lymphatic vessels.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Lymph node biophysical remodeling is associated with melanoma lymphatic drainage.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Mechanobiological oscillators control lymph flow.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Bridging the divide between pathogenesis and detection in lymphedema.Seminars in cell & developmental biology · 2015Review
- Tissue-engineered lymphatic graft for the treatment of lymphedema.The Journal of surgical research · 2014Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In addition to external forces, collecting lymphatic vessels intrinsically contract to transport lymph from the extremities to the venous circulation. As a result, the lymphatic endothelium is routinely exposed to a wide range of dynamic mechanical forces, primarily fluid shear stress and circumferential stress, which have both been shown to affect lymphatic pumping activity. Although various ex vivo perfusion systems exist to study this innate pumping activity in response to mechanical stimuli, none are capable of independently controlling the two primary mechanical forces affecting lymphatic contractility: transaxial pressure gradient, [Formula: see text], which governs fluid shear stress; and average transmural pressure, [Formula: see text], which governs circumferential stress. Hence, the authors describe a novel ex vivo lymphatic perfusion system (ELPS) capable of independently controlling these two outputs using a linear, explicit model predictive control (MPC) algorithm. The ELPS is capable of reproducing arbitrary waveforms within the frequency range observed in the lymphatics in vivo, including a time-varying [Formula: see text] with a constant [Formula: see text], time-varying [Formula: see text] and [Formula: see text], and a constant [Formula: see text] with a time-varying [Formula: see text]. In addition, due to its implementation of syringes to actuate the working fluid, a post-hoc method of estimating both the flow rate through the vessel and fluid wall shear stress over multiple, long (5 s) time windows is also described.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.