ArticleJournal of neural transmission (Vienna, Austria : 1996)2014
Characteristics and occurrence of speech impairment in Huntington's disease: possible influence of antipsychotic medication.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- A Systematic Review of Rehabilitation for Corticobulbar Symptoms in Adults with Huntington's Disease.Journal of Huntington's disease · 2020Pooled it
- Speech and swallowing rehabilitation in Huntington's disease: clinical outcomes and correlations with disease severity.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Observational
- Development and validation of a machine learning model to detect psychiatric symptoms in Huntington's disease using speech analysis.PloS one · 2026Article
- Challenging or less challenging oral diadochokinetic tasks-what works best in Huntington disease? A cross-sectional study.Journal of neurology · 2025Article
- Disease-Specific Speech Movement Characteristics of the Tongue and Jaw.Journal of speech, language, and hearing research : JSLHR · 2025Article
- Article
- An acoustic model of speech dysprosody in patients with Parkinson's disease.Frontiers in human neuroscience · 2025Article
- Exploring the Relationships Between Antipsychotic Dosage and Voice Characteristics in Relation to Extrapyramidal Symptoms.Psychiatry investigation · 2024Article
- An automatic measure for speech intelligibility in dysarthrias-validation across multiple languages and neurological disorders.Frontiers in digital health · 2024Article
- Vowel Acoustics as Predictors of Speech Intelligibility in Dysarthria.Journal of speech, language, and hearing research : JSLHR · 2023Article
- Predicting clinical scores in Huntington's disease: a lightweight speech test.Journal of neurology · 2022Article
- Using a Clinical Formulation to Understand Psychological Distress in People Affected by Huntington's Disease: A Descriptive, Evidence-Based Model.Journal of personalized medicine · 2022Article
- Dysarthria Subgroups in Talkers with Huntington's Disease: Comparison of Two Data-Driven Classification Approaches.Brain sciences · 2022Article
- Characterizing Dysarthria Diversity for Automatic Speech Recognition: A Tutorial from the Clinical Perspective.Frontiers in computer science · 2022Article
- Language disturbances in schizophrenia: the relation with antipsychotic medication.NPJ schizophrenia · 2020Article
- Motor speech patterns in Huntington disease.Neurology · 2019Article
- Speech-Language Pathology Evaluation and Management of Hyperkinetic Disorders Affecting Speech and Swallowing Function.Tremor and other hyperkinetic movements (New York, N.Y.) · 2017Review
- Article
- Automatic Evaluation of Speech Rhythm Instability and Acceleration in Dysarthrias Associated with Basal Ganglia Dysfunction.Frontiers in bioengineering and biotechnology · 2015Article
- Speech disorders reflect differing pathophysiology in Parkinson's disease, progressive supranuclear palsy and multiple system atrophy.Journal of neurology · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although motor speech impairment is a common manifestation of Huntington's disease (HD), its description remains limited. The aim of the current study was therefore to estimate the occurrence and characteristics of speech disorder in HD and to explore the influence of antipsychotic medication on speech performance. Speech samples, including reading passage and monologue, were acquired from 40 individuals diagnosed with HD and 40 age- and sex-matched healthy controls. Objective acoustic analyses were used to evaluate key aspects of speech including vowel articulation, intensity, pitch and timing. A predictive model was constructed to detect the occurrence and most prominent patterns of speech dysfunction in HD. We revealed that 93% of HD patients manifest some degree of speech impairment. Decreased number of pauses, slower articulation rate, imprecise vowel articulation and excess intensity variations were found to be the most salient patterns of speech dysfunction in HD. We further demonstrated that antipsychotic medication may induce excessive loudness and pitch variations perceptually resembling excess patterns of word stress, and may also accentuate general problems with speech timing. Additionally, antipsychotics induced a slight improvement of vowel articulation. Specific speech alterations observed in HD patients indicate that speech production may reflect the pathophysiology of the disease as well as treatment effects, and may therefore be considered a valuable marker of functional disability in HD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.