ArticlePLoS genetics2014
Population genomic analysis of ancient and modern genomes yields new insights into the genetic ancestry of the Tyrolean Iceman and the genetic structure of Europe.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49 citing papers in PubMed, 98 citations in OpenAlex.
- Graph transformer for ancient ancestry inference.bioRxiv : the preprint server for biology · 2026Article
- Reassessing neolithic subsistence in Northern Italy through a critical review and new evidence from Molino Casarotto.Scientific reports · 2025Review
- The genomic footprints of migration: how ancient DNA reveals our history of mobility.Genome biology · 2025Review
- Flame-forged divergence? Ancient human fires and the evolution of diurnal and nocturnal lineages in moorish geckos.iScience · 2025Article
- Genetic Diversity Based on Human Y Chromosome Analysis: A Bibliometric Review Between 2014 and 2023.Cureus · 2024Review
- Evolutionary immuno-genetics of endoplasmic reticulum aminopeptidase II (ERAP2).Genes and immunity · 2023Review
- Bioarchaeological and paleogenomic profiling of the unusual Neolithic burial from Grotta di Pietra Sant'Angelo (Calabria, Italy).Scientific reports · 2023Article
- Article
- A Protective HLA Extended Haplotype Outweighs the Major COVID-19 Risk Factor Inherited From Neanderthals in the Sardinian Population.Frontiers in immunology · 2022Article
- [The Iceman : Life scenarios and pathological findings from 30 years of research on the glacier mummy "Ötzi"].Der Pathologe · 2021Review
- Human population dynamics andScience advances · 2021Article
- Population genetics of wild Macaca fascicularis with low-coverage shotgun sequencing of museum specimens.American journal of physical anthropology · 2020Article
- Beyond broad strokes: sociocultural insights from the study of ancient genomes.Nature reviews. Genetics · 2020Review
- Genomic history of the Italian population recapitulates key evolutionary dynamics of both Continental and Southern Europeans.BMC biology · 2020Article
- The spatiotemporal spread of human migrations during the European Holocene.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Corded Ware cultural complexity uncovered using genomic and isotopic analysis from south-eastern Poland.Scientific reports · 2020Article
- The spread of steppe and Iranian-related ancestry in the islands of the western Mediterranean.Nature ecology & evolution · 2020Article
- Genetic history from the Middle Neolithic to present on the Mediterranean island of Sardinia.Nature communications · 2020Article
- Y-chromosome and Surname Analyses for Reconstructing Past Population Structures: The Sardinian Population as a Test Case.International journal of molecular sciences · 2019Article
- EGFR, KRAS, BRAF, ALK, and cMET genetic alterations in 1440 Sardinian patients with lung adenocarcinoma.BMC pulmonary medicine · 2019Article
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Authors and funding
25 authors at 11 institutions in 6 countries.
Funding
Abstract
Genome sequencing of the 5,300-year-old mummy of the Tyrolean Iceman, found in 1991 on a glacier near the border of Italy and Austria, has yielded new insights into his origin and relationship to modern European populations. A key finding of that study was an apparent recent common ancestry with individuals from Sardinia, based largely on the Y chromosome haplogroup and common autosomal SNP variation. Here, we compiled and analyzed genomic datasets from both modern and ancient Europeans, including genome sequence data from over 400 Sardinians and two ancient Thracians from Bulgaria, to investigate this result in greater detail and determine its implications for the genetic structure of Neolithic Europe. Using whole-genome sequencing data, we confirm that the Iceman is, indeed, most closely related to Sardinians. Furthermore, we show that this relationship extends to other individuals from cultural contexts associated with the spread of agriculture during the Neolithic transition, in contrast to individuals from a hunter-gatherer context. We hypothesize that this genetic affinity of ancient samples from different parts of Europe with Sardinians represents a common genetic component that was geographically widespread across Europe during the Neolithic, likely related to migrations and population expansions associated with the spread of agriculture.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.