ArticlePloS one2014
Strengths and limitations of period estimation methods for circadian data.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 212 papers.
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Who cites it
212 citing papers in PubMed.
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- The Circadian Oscillator Affects Both Glutathione Homeostasis and Its Response to Salt Stress in Arabidopsis thaliana.Plant, cell & environment · 2026Article
- A noncoding SNP in ELF3 alters ELF3β expression and confers adaptation of Arabidopsis to a continental climate.Plant physiology · 2026Article
- Thermal imaging as a tool for studying circadian rhythms in roots.The Plant journal : for cell and molecular biology · 2026Article
- Vernalisation-induced changes to the Arabidopsis circadian clock require Polycomb Repressive Complex 2 and are FLC-independent.Plant & cell physiology · 2026Article
- Cellular- and systems-level profiling of amyloid-beta effects on circadian timing.Neurobiology of disease · 2026Article
- Nuclear basket localized proteasomes maintain circadian period through nuclear TOC1 proteolysis.bioRxiv : the preprint server for biology · 2026Article
- A PROMOTER::LUCIFERASE reporter system reveals key elements of the circadian regulation of Crassulacean acid metabolism (CAM) in Kalanchoë laxiflora Baker.The Plant journal : for cell and molecular biology · 2026Article
- Daily rhythms modulate Acinetobacter baumannii physiology impacting infection outcome and antibiotic-inactivating capacity.Scientific reports · 2026Article
- Intracellular potassium levels orchestrate circadian rhythmicity and cell division.Nature communications · 2026Article
- Circadian control of a sex-specific behavior ineLife · 2026Article
- Seasonal variation in activity rhythms of leopard cats (Prionailurus bengalensis), their prey and competitors in southern Anhui.Scientific reports · 2026Article
- Effects of the signaling molecule cyclic-di-GMP on cyanobacterial circadian rhythm inJournal of bacteriology · 2026Article
- Circadian clock proteins KaiB and Rbp2 ofMicrobiology spectrum · 2026Article
- Mechanism and reconstitution of circadian transcription in cyanobacteria.Nature structural & molecular biology · 2026Article
- Article
- Hypothalamic deiodinase type-3 establishes the period of circannual interval timing in mammals.eLife · 2026Article
152 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
A key step in the analysis of circadian data is to make an accurate estimate of the underlying period. There are many different techniques and algorithms for determining period, all with different assumptions and with differing levels of complexity. Choosing which algorithm, which implementation and which measures of accuracy to use can offer many pitfalls, especially for the non-expert. We have developed the BioDare system, an online service allowing data-sharing (including public dissemination), data-processing and analysis. Circadian experiments are the main focus of BioDare hence performing period analysis is a major feature of the system. Six methods have been incorporated into BioDare: Enright and Lomb-Scargle periodograms, FFT-NLLS, mFourfit, MESA and Spectrum Resampling. Here we review those six techniques, explain the principles behind each algorithm and evaluate their performance. In order to quantify the methods' accuracy, we examine the algorithms against artificial mathematical test signals and model-generated mRNA data. Our re-implementation of each method in Java allows meaningful comparisons of the computational complexity and computing time associated with each algorithm. Finally, we provide guidelines on which algorithms are most appropriate for which data types, and recommendations on experimental design to extract optimal data for analysis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.