ArticleJournal of the American College of Nutrition2014
Serum coenzyme Q₁₀, α-tocopherol, γ-tocopherol, and C-reactive protein levels and body mass index in adolescent and premenopausal females.
Article in Journal of the American College of Nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Adherence to cancer prevention recommendations and antioxidant and inflammatory status in premenopausal women.The British journal of nutrition · 2015Trial
- Association of Coenzyme Q10 with Premature Ovarian Insufficiency.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Association of serum levels of antioxidant micronutrients with mortality in US adults: National Health and Nutrition Examination Survey 1999-2002.Public health nutrition · 2021Article
- Article
- Circulating γ-Tocopherol Concentrations Are Inversely Associated with Antioxidant Exposures and Directly Associated with Systemic Oxidative Stress and Inflammation in Adults.The Journal of nutrition · 2018Article
- Complexity of vitamin E metabolism.World journal of biological chemistry · 2016Review
- Coenzyme Q10 Status as a Determinant of Muscular Strength in Two Independent Cohorts.PloS one · 2016Article
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveLipid-soluble antioxidants are associated with a lower incidence for many chronic diseases of aging, possibly by preventing damage from chronic inflammation. In the current study, we compared serum levels of coenzyme Q₁₀ (CoQ₁₀), α-tocopherol, γ-tocopherol, and C-reactive protein (CRP) between adolescent girls and premenopausal women to assess changes from childhood to midlife.
methodsBaseline serum CoQ₁₀, α-tocopherol, γ-tocopherol, and CRP levels were measured in 207 girls (13-19 years) and 183 premenopausal women (34-47 years) using standard methods and the 2 age groups were compared by t test. The influence of age, body mass index (BMI), and race/ethnicity and interaction effects on serum values were assessed using analysis of covariance. Pearson correlation coefficients were used to assess associations between pairs of lipid micronutrients.
resultsOverall, adolescent girls had significantly lower mean serum CoQ₁₀, α-tocopherol, γ-tocopherol, and CRP levels relative to premenopausal women (CoQ10: 376 vs 544 ng/mL, p < 0.0001; α-tocopherol: 6.9 vs 13.5 μg/mL, p < 0.0001; γ-tocopherol: 1.3 vs 1.7 μg/mL, p < 0.0001; CRP: 1.29 vs 2.13 mg/L, p < 0.0001). The differences in CoQ₁₀ and tocopherols remained significant after adjustment for BMI and race/ethnicity. CoQ₁₀ was significantly and positively correlated to α- and γ-tocopherol, and BMI was positively associated with CRP and γ-tocopherol in both groups.
conclusionsLower serum CoQ₁₀, α-tocopherol, γ-tocopherol, and CRP levels in adolescent girls compared to women suggests that adolescents may have a reduced need for antioxidants possibly due to their lower BMI and inflammatory status as indicated by CRP.
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